380487-65-0 Usage
General Description
Alpha-epoxydihydroartemisinic acid is a chemical compound derived from the natural product artemisinin, which is found in the sweet wormwood plant (Artemisia annua). alpha-Epoxydihydroartemisinic acid is a semi-synthetic precursor to artemisinin, a key ingredient in the most effective treatment for malaria. Alpha-epoxydihydroartemisinic acid plays a critical role in the industrial production of artemisinin, as it can be converted into the active ingredient through a series of chemical reactions. alpha-Epoxydihydroartemisinic acid has contributed to the availability of artemisinin-based combination therapies (ACTs) for the treatment of malaria, which have become a cornerstone of efforts to combat the disease worldwide. Additionally, research on alpha-epoxydihydroartemisinic acid continues to explore its potential in the development of new antimalarial drugs and the improvement of current treatment options.
Check Digit Verification of cas no
The CAS Registry Mumber 380487-65-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,8,0,4,8 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 380487-65:
(8*3)+(7*8)+(6*0)+(5*4)+(4*8)+(3*7)+(2*6)+(1*5)=170
170 % 10 = 0
So 380487-65-0 is a valid CAS Registry Number.
380487-65-0Relevant articles and documents
Syntheses of dihydroartemisinic acid and dihydro-epi-deoxyarteannuin B incorporating a stable isotope label at the 15-position for studies into the biosynthesis of artemisinin
Sy, Lai-King,Zhu, Nian-Yong,Brown, Geoffrey D
, p. 8495 - 8510 (2007/10/03)
[15-13C2H3]-Dihydroartemisinic acid (3a) and [15-13CH3]-dihydro-epi-deoxyarteannuin B (7b), intended for evaluation in vivo as biosynthetic precursors to artemisinin, have been obtained from a reconstructive synthesis. The decalenone acid 8 from acid degradation of artemisinin (1) serves as a common intermediate: following addition of labeled methyl Grignard reagent to 8, either labeled precursor can be prepared in good yield by varying the work-up conditions employed. It is shown that both compounds are prone to autoxidation on storage and that the products of such oxidation and subsequent rearrangement reactions might be confused with bona fide metabolites when using these labeled precursors in feeding experiments designed to determine the biosynthetic route to artemisinin in Artemisia annua.
