380567-18-0

Basic information

• Product Name: Benzoic acid, 4-[(2,3-dihydro-2,3-dioxo-1H-indol-1-yl)methyl]-, methyl ester
• CAS NO: 380567-18-0
• Molecular Formula: C17H13NO4
• Molecular Weight: 295.295
• Mol File: 380567-18-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[(2,3-dihydro-2,3-dioxo-1H-indol-1-yl)methyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(2,3-dihydro-2,3-dioxo-1H-indol-1-yl)methyl]-, methyl ester(380567-18-0)
• EPA Substance Registry System: Benzoic acid, 4-[(2,3-dihydro-2,3-dioxo-1H-indol-1-yl)methyl]-, methyl ester(380567-18-0)

Safety Data

• Hazardous Substances Data: 380567-18-0(Hazardous Substances Data)

Upstream product

• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 91-56-5 indole-2,3-dione 
• 99-94-5 p-Toluic acid 
• 99-75-2 4-methyl-benzoic acid methyl ester 

Downstream Products

• 1380087-59-1 1,1'-bis(4-methoxycarbonylbenzyl)-3,3'-biindolinylidene-2,2'-dione 

Relevant articles and documents

Design, synthesis and evaluation of novel indirubin-based N-hydroxybenzamides, N-hydroxypropenamides and N-hydroxyheptanamides as histone deacetylase inhibitors and antitumor agents

Several novel indirubin-based N-hydroxybenzamides, N-hydropropenamides and N-hydroxyheptanamides (4a-h, 7a-h, 10a-h) were designed using a fragment-based approach with structural features extracted from several previously reported HDAC inhibitors, such as

Novel Indirubin-based N-Hydroxybenzamides, N-Hydroxypropenamides and N-Hydroxyheptanamides and its use

The present invention relates to novel indirubin-based N-hydroxybenzamide, N-hydroxypropanamide and N-hydroxyheptanamide compounds as histone deacetylase (HDAC) inhibitors, and an anticancer composition comprising the same as an active component. More specifically, the compound according to the present invention has strong HDAC inhibitory activity, thereby being able to be used as a proliferation inhibitor for various cancer cells. Therefore, it is expected that the compound according to the present invention can be developed as an active component of a powerful anticancer agent.

Novel N-hydroxybenzamide and Use Thereof

The present invention relates to a novel N-hydroxybenzamide and to uses thereof. More specifically, the present invention provides the novel N-hydroxybenzamide-based compound useful as histone deacetylase inhibitors, and compositions comprising the same, wherein the compound according to the present invention is useful as a medicine for treatment and prevention of cancer.COPYRIGHT KIPO 2018