38059-09-5

Basic information

• Product Name: (2-{[2-(HYDROXYMETHYL)PHENYL]THIO}PHENYL)METHANOL
• Synonyms: (2-{[2-(HYDROXYMETHYL)PHENYL]THIO}PHENYL)METHANOL;BIS(2-HYDROXYMETHYLPHENYL)SULFIDE;[2-[(2-methylolphenyl)thio]phenyl]methanol;[2-[2-(hydroxymethyl)phenyl]sulfanylphenyl]methanol
• CAS NO: 38059-09-5
• Molecular Formula: C₁₄H₁₄O₂S
• Molecular Weight: 246.32476
• Mol File: 38059-09-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 397.1 °C at 760 mmHg
• Flash Point: 192.9 °C
• Appearance: /
• Density: 1.28 g/cm³
• Vapor Pressure: 5.09E-07mmHg at 25°C
• Refractive Index: 1.673
• CAS DataBase Reference: (2-{[2-(HYDROXYMETHYL)PHENYL]THIO}PHENYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2-{[2-(HYDROXYMETHYL)PHENYL]THIO}PHENYL)METHANOL(38059-09-5)
• EPA Substance Registry System: (2-{[2-(HYDROXYMETHYL)PHENYL]THIO}PHENYL)METHANOL(38059-09-5)

Safety Data

• Hazardous Substances Data: 38059-09-5(Hazardous Substances Data)

Usage

General Description

(2-{[2-(hydroxymethyl)phenyl]thio}phenyl)methanol is a chemical compound with the molecular formula C14H14OS. It is a derivative of phenol, containing a thiol and a hydroxymethyl group on the phenyl ring. The compound is a white solid that is soluble in organic solvents. It has applications in organic synthesis and pharmaceutical research, particularly in the development of molecules with potential therapeutic properties. The presence of the thiol and hydroxymethyl groups makes it a versatile building block for the synthesis of various functionalized compounds. Additionally, it may have potential uses in the field of materials science and as a reagent in chemical processes.

InChI:InChI=1/C14H14O2S/c15-9-11-5-1-3-7-13(11)17-14-8-4-2-6-12(14)10-16/h1-8,15-16H,9-10H2

Upstream product

• 50-00-0 formaldehyd 
• 2362-50-7 thianthrene-5-oxide 
• 88-65-3 2-bromobenzoic-acid 
• 147-93-3 Thiosalicylic acid 
• 139-66-2 diphenyl sulfide 
• 118-91-2 ortho-chlorobenzoic acid 
• 100541-19-3 2,2'-thiodibenzoic acid chloride 
• 22219-02-9 2,2'-thiodibenzoic acid 
• 7732-18-5 water 
• 49590-24-1 2,2'-Thiobenzoesaeure-dimethylester 

Downstream Products

• 63743-97-5 bis(2-hydroxymethylphenyl)sulfoxide 
• 133620-59-4 [2-(2-Mercaptomethyl-phenylsulfanyl)-phenyl]-methanethiol 
• 93012-55-6 2-(2-((6-carboxymethylphenyl)thio)phenyl)acetic acid 
• 1062600-68-3 2-(2-((6-cyanomethylphenyl)thio)phenyl)acetonitrile 
• 1443212-52-9 C₁₄H₁₀O₃S 
• 549494-75-9 bis-(2-formylphenyl)thioether 
• 1062600-79-6 di(chloromethylphenyl) thioether 
• 1062600-53-6 1-(2-cyanoethyl)-2-((6-(2-cyanoethyl)phenyl)thio)benzene 

Relevant articles and documents

Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors

Inhibition of intestinal brush border DMT1 offers a novel therapeutic approach to the prevention and treatment of disorders of iron overload. Several series of diaryl and tricyclic benzylisothiourea compounds as novel and potent DMT1 inhibitors were discovered from the original hit compound 1. These compounds demonstrated in vitro potency against DMT1, desirable cell permeability properties and a dose-dependent inhibition of iron uptake in an acute rat model of iron hyperabsorption. Tricyclic compounds increased the in vitro potency by up to 16-fold versus the original hit. Diaryl compounds 6b and 14a demonstrated significant iron absorption inhibition in vivo with both 25 and 50 mg/kg doses. The diaryl and tricyclic compounds described in this report represent promising structural templates for further optimization.

BIARYL AND BIHETEROARYL COMPOUNDS USEFUL IN TREATING IRON DISORDERS

This invention is directed to compounds of formula (I): wherein m, n, R1, R2 and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment of iron disorders. This invention is also directed to pharmaceutical compositions comprising the compounds and methods of using the compounds to treat iron disorders.

Reactions of Sulfoxides Bearing ortho-Sulfur Functional Groups and Thianthrene Monoxide with Grignard Reagents

Diaryl sulfoxides bearing ortho-sulfur substituents react readily with Grignard reagents on the sulfur atom to produce the corresponding phenyl Grignard reagents bearing ortho-sulfur functional group.Furthermore, thianthrene monooxide was found to react with alkyl Grignard reagents affording o,o'-bis-Grignard reagent of diphenyl sulfide which was converted easily to Martin's sulfurane.