38061-20-0Relevant articles and documents
Preparation of pyrrol and oxazole compounds; formation of porphyrins and C-acyl-α-amino acid esters therefrom
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, (2008/06/13)
A process for preparation of new or previously known pyrrol derivatives is provided. The process involves reacting a nitroalkane or a nitroalkene with an isocyanoacetate in the presence of a prophosphatrane "super base" to prepare the pyrrol compounds. Th
Nonionic superbase-promoted synthesis of oxazoles and pyrroles: Facile synthesis of porphyrins and α-C-acyl amino acid esters
Tang,Verkade
, p. 7793 - 7802 (2007/10/02)
The reaction of acyl chlorides or acid anhydrides with isocyanoacetates in the presence of the superior strong nonionic base P(MeNCH2CH2)3N (1) gave oxazoles in 98-99% yield. Treatment of the oxazoles with HCl-MeOH gave α-