3807-77-0

Basic information

• Product Name: 3-NITROACENAPHTHENE
• Synonyms: Acenaphthene, 3-nitro-
• CAS NO: 3807-77-0
• Molecular Formula: C₁₂H₉NO₂
• Molecular Weight: 0
• Product Categories: Naphthalene derivatives
• Mol File: 3807-77-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 389.8°Cat760mmHg
• Flash Point: 200.3°C
• Appearance: /
• Density: 1.357g/cm³
• Vapor Pressure: 6.22E-06mmHg at 25°C
• Refractive Index: 1.723
• CAS DataBase Reference: 3-NITROACENAPHTHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITROACENAPHTHENE(3807-77-0)
• EPA Substance Registry System: 3-NITROACENAPHTHENE(3807-77-0)

Safety Data

• Hazardous Substances Data: 3807-77-0(Hazardous Substances Data)

Usage

Uses

3-Nitroacenaphthene is an impurity of Acenaphthene (D448330), which is a polycyclic aromatic hydrocarbon as carcinogenic agent.

InChI:InChI=1/C12H9NO2/c14-13(15)11-7-5-9-3-1-2-8-4-6-10(11)12(8)9/h1-3,5,7H,4,6H2

Upstream product

• 83-32-9 acenaphthene 
• 7697-37-2 nitric acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 3807-76-9 3,6-dinitroacenaphthene 
• 35338-47-7 3,8-dinitro-acenaphthene 
• 42101-93-9 2-nitro-naphthalene-1,8-dicarboxylic acid 
• 865758-20-9 3-phenyl-acenaphthylene 
• 5209-31-4 3-bromoacenaphthene 
• 55939-13-4 1,2-dihydro-acenaphthylene-3-amine 
• 10353-98-7 3-Nitroacenaphthylen 

Relevant articles and documents

Synthesis and study of antiproliferative, antitopoisomerase II, DNA-intercalating and DNA-damaging activities of arylnaphthalimides

A series of arylnaphthalimides were designed and synthesized to overcome the dose-limiting cytotoxicity of N-acetylated metabolites arising from amonafide, the prototypical antitumour naphthalimide whose biomedical properties have been related to its ability to intercalate the DNA and poison the enzyme Topoisomerase II. Thus, these arylnaphthalimides were first evaluated for their antiproliferative activity against two tumour cell lines and for their antitopoisomerase II in vitro activities, together with their ability to intercalate the DNA in vitro and also through docking modelization. Then, the well-known DNA damage response in Saccharomyces cerevisiae was employed to critically evaluate whether these novel compounds can damage the DNA in vivo. By performing all these assays we conclude that the 5-arylsubstituted naphthalimides not only keep but also improve amonafide's biological activities.