38076-78-7

Basic information

• Product Name: 2-AMINO-5-METHYLNICOTINONITRILE
• Synonyms: 2-AMINO-5-METHYLNICOTINONITRILE;2-AMINO-3-CYANO-5-PICOLINE;2-aMino-5-Methyl-3-Pyridinecarbonitrile
• CAS NO: 38076-78-7
• Molecular Formula: C7H7N3
• Molecular Weight: 133.15
• Product Categories: Pyridine
• Mol File: 38076-78-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 310.56 °C at 760 mmHg
• Flash Point: 141.622 °C
• Appearance: /
• Density: 1.184g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-AMINO-5-METHYLNICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-METHYLNICOTINONITRILE(38076-78-7)
• EPA Substance Registry System: 2-AMINO-5-METHYLNICOTINONITRILE(38076-78-7)

Safety Data

• Hazardous Substances Data: 38076-78-7(Hazardous Substances Data)

Usage

General Description

2-AMINO-5-METHYLNICOTINONITRILE is a chemical compound with the molecular formula C7H8N3. It is a derivative of nicotinonitrile, and its structure includes an amino group and a methyl group attached to the five-carbon of the nicotinonitrile ring. 2-AMINO-5-METHYLNICOTINONITRILE is used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical products. Its properties and reactivity make it suitable for use in the production of anti-inflammatory, anti-cancer, and antibacterial medications. Additionally, 2-AMINO-5-METHYLNICOTINONITRILE is also used as a key intermediate in the synthesis of agrochemicals and other fine chemical products.

InChI:InChI=1/C7H7N3/c1-5-2-6(3-8)7(9)10-4-5/h2,4H,1H3,(H2,9,10)

Upstream product

• 91752-76-0 3-aminomethacrylaldehyde 
• 55244-11-6 ethyl cyanoacetimidate hydrochloride 
• 544-92-3 copper(I) cyanide 
• 17282-00-7 3-bromo-5-methylpyridin-2-amine 
• 123-38-6 propionaldehyde 
• 122-51-0 orthoformic acid triethyl ester 
• 4341-85-9 malonitrile 
• 52833-34-8 propylidenemalonitrile 
• 154420-85-6 (+/-)-5-Methyl-2-(1-phenylethylamino)nicotinonitril 
• 85147-08-6 2-cyano-4-methyl-5-piperidino-1,3-pentadienylnitrile 
• 85147-09-7 2-amino-3-cyano-5-methylpyridine 1-oxide 
• 65995-93-9 2-((E)-3-Ethoxy-2-methyl-allylidene)-malononitrile 
• 67-56-1 methanol 
• 65995-95-1 1,1-dicyano-4-ethoxy-3-methyl-1,3-butadiene 

Relevant articles and documents

HETEROARYL INHIBITORS OF PAD4

The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.

An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6]

A practical Pd(PPh3)4/DBU catalytic system for the synthesis of pharmaceutically relevant aminopyridine nitrile intermediates, as well as a variety of other aryl nitriles using non-toxic K4[Fe(CN) 6] has been developed. The key features of our new protocol for cyanation lie in that the reaction can be carried out with readily available Pd(PPh3)4 under mild and green conditions, even without the assistance of other ligands. The Royal Society of Chemistry 2012.

Substituted 2-aminonicotinonitriles

Aminolysis of the cyanoketene-O,N-acetal 1 Z/E with the amines 2a,b leads to the E-configurated cyanoketeneaminals 3a,b. Compounds 3a,b are reacted with 1,3-biselectrophiles 4, 6a,b, 9 HCl, 12, 13, 15a,b, 17, and 19 to yield the N2-substituted 2-aminonicotinonitriles 5, 7, 8, 10, 11, 14, 16, and 20. Reaction of some 2-aminonicotinonitriles with an α-phenylethyl substituent in position 2 (14b, 16a, 8a, 20b, 5 and 8b) with PPA leads to the primary 2-aminonicotinonitriles 21a-f.