3810-23-9

Basic information

• Product Name: 2-METHYL-4H-PYRIDO[4,3-D][1,3]OXAZIN-4-ONE
• Synonyms: 2-METHYL-4H-PYRIDO[4,3-D][1,3]OXAZIN-4-ONE;4H-Pyrido[4,3-d][1,3]oxazin-4-one, 2-methyl-;2-Methyl-pyrido[4,3-d][1,3]oxazin-4-one
• CAS NO: 3810-23-9
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.15
• Mol File: 3810-23-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 156-159 °C
• Boiling Point: 318.2 °C at 760 mmHg
• Flash Point: 146.2 °C
• Appearance: /
• Density: 1.39g/cm³
• Vapor Pressure: 0.000368mmHg at 25°C
• Refractive Index: 1.649
• PKA: 5.02±0.20(Predicted)
• CAS DataBase Reference: 2-METHYL-4H-PYRIDO[4,3-D][1,3]OXAZIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-4H-PYRIDO[4,3-D][1,3]OXAZIN-4-ONE(3810-23-9)
• EPA Substance Registry System: 2-METHYL-4H-PYRIDO[4,3-D][1,3]OXAZIN-4-ONE(3810-23-9)

Safety Data

• Hazardous Substances Data: 3810-23-9(Hazardous Substances Data)

Usage

General Description

2-Methyl-4H-pyrido[4,3-d][1,3]oxazin-4-one is a chemical compound with a heterocyclic structure. It is a fused pyridine and oxazine ring system with a methyl group attached to the nitrogen atom in the pyridine ring. 2-METHYL-4H-PYRIDO[4,3-D][1,3]OXAZIN-4-ONE is a cyclic imide and can be synthesized through various chemical reactions. It may have potential uses in the pharmaceutical and agrochemical industries, although further research is needed to fully understand its properties and potential applications. Additionally, its biological and toxicological properties are not well-documented, so caution should be exercised when handling and using this compound.

InChI:InChI=1/C8H6N2O2/c1-5-10-7-2-3-9-4-6(7)8(11)12-5/h2-4H,1H3

Upstream product

• 88511-27-7 3-iodopyridin-4-amine 
• 201230-82-2 carbon monoxide 
• 108-24-7 acetic anhydride 
• 7418-65-7 4-aminonicotinic acid 
• 78-39-7 Triethyl orthoacetate 
• 16952-67-3 4-benzoylamino-nicotinic acid 
• 60770-86-7 4-(acetylamino)nicotinic acid 

Downstream Products

• 936744-17-1 (E)-2-(2-hydroxy-3-methoxystyryl)-3-phenylpyrido[4,3-d]pyrimidin-4(3H)-one 
• 16952-69-5 2-methyl-3-phenylpyrido[4,3-d]pyrimidin-4(3H)-one 

Relevant articles and documents

Recyclable palladium-catalyzed carbonylative annulation of 2-iodoanilines with acid anhydrides: A practical synthesis of 2-alkylbenzoxazinones

A highly efficient heterogeneous palladium-catalyzed carbonylative annulation of 2-iodoanilines and acid anhydrides has been developed. The reaction proceeds effectively in toluene using N,N-diisopropylethylamine (DiPEA) as the base at 100 °C under 2 bar of CO and provides a novel, general, and practical method for the assembly of a wide variety of 2-alkylbenzoxazinones with high functional group tolerance and good to excellent yields. This supported palladium complex can be readily separated from the product and recovered by a simple filtration of the reaction solution and reused up to seven times with almost consistent catalytic efficiency.

Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials

We recently reported on the discovery of a novel antibacterial (2) with a 4(3H)-quinazolinone core. This discovery was made by in silico screening of 1.2 million compounds for binding to a penicillin-binding protein and the subsequent demonstration of antibacterial activity against Staphylococcus aureus. The first structure-activity relationship for this antibacterial scaffold is explored in this report with evaluation of 77 variants of the structural class. Eleven promising compounds were further evaluated for in vitro toxicity, pharmacokinetics, and efficacy in a mouse peritonitis model of infection, which led to the discovery of compound 27. This new quinazolinone has potent activity against methicillin-resistant (MRSA) strains, low clearance, oral bioavailability and shows efficacy in a mouse neutropenic thigh infection model.

Compounds for modulating TRPV3 function

The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.