38142-58-4Relevant articles and documents
Dimethyl (2-Oxo-4-methyl-3-pentenyl)phosphonate as a Precursor of α,α'-Dienones. Short Syntheses of (+/-)-α-Atlantone and (+/-)-ar-Turmerone
Motoyoshiya, Jiro,Miyajima, Masae,Hirakawa, Kiyoichi,Kakurai, Toshio
, p. 1326 - 1327 (1985)
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Directed Markovnikov hydroarylation and hydroalkenylation of alkenes under nickel catalysis
Apolinar, Omar,Deng, Ruohan,Engle, Keary M.,Li, Zi-Qi
, p. 11038 - 11044 (2021/08/31)
We report a full account of our research on nickel-catalyzed Markovnikov-selective hydroarylation and hydroalkenylation of non-conjugated alkenes, which has yielded a toolkit of methods that proceed under mild conditions with alkenyl sulfonamide, ketone, and amide substrates. Regioselectivity is controlled through catalyst coordination to the native Lewis basic functional groups contained within these substrates. To maximize product yield, reaction conditions were fine-tuned for each substrate class, reflecting the different coordination properties of the directing functionality. Detailed kinetic and computational studies shed light on the mechanism of this family of transformations, pointing to transmetalation as the turnover-limiting step.
Application of Meldrum's acid in natural product synthesis. Synthesis of ar-turmerone and α-curcumene
Mahulikar,Mane
, p. 15 - 18 (2007/10/03)
Meldrum's acid (1) is employed in the synthesis of ar-turmerone (6) and α-curcumene (12). 1-(p-Tolyl)ethyl Meldrum's acid (3), synthesised by three different routes, was the key intermediate in these syntheses.