38145-93-6 Usage
Description
(R)-1-[(4R,4'R)-2,2,2',2'-Tetramethyl-4α,4'β-bi[1,3-dioxolane]-5β-yl]ethane-1,2-diol is a chiral compound characterized by its central ethane-1,2-diol core and two 2,2,2',2'-tetramethyl-4α,4'β-bi[1,3-dioxolane] groups. With a molecular formula of C18H34O6 and a molecular weight of 346.46 g/mol, this compound is recognized for its unique structure and potential applications in various fields, including drug development and material science. Its stereochemistry and functional groups make it a valuable asset in the synthesis of complex molecules and the exploration of biological activities.
Uses
Used in Pharmaceutical Research:
(R)-1-[(4R,4'R)-2,2,2',2'-Tetramethyl-4α,4'β-bi[1,3-dioxolane]-5β-yl]ethane-1,2-diol is used as a building block for the development of new pharmaceutical compounds due to its unique structure and stereochemistry. Its functional groups and molecular configuration allow for the creation of complex molecules with potential therapeutic applications.
Used in Material Science:
In the field of material science, (R)-1-[(4R,4'R)-2,2,2',2'-Tetramethyl-4α,4'β-bi[1,3-dioxolane]-5β-yl]ethane-1,2-diol is utilized as a key component in the synthesis of novel materials with specific properties. Its incorporation into these materials can lead to advancements in areas such as polymer development, nanotechnology, and other material innovations.
Used in Organic Synthesis:
As a chiral compound, (R)-1-[(4R,4'R)-2,2,2',2'-Tetramethyl-4α,4'β-bi[1,3-dioxolane]-5β-yl]ethane-1,2-diol is employed as an essential building block in organic synthesis. Its stereochemistry and functional groups enable the creation of a wide range of complex molecules, which can be further explored for their potential applications in various industries, including pharmaceuticals, agrochemicals, and specialty chemicals.
Used in Drug Development:
In the pharmaceutical industry, (R)-1-[(4R,4'R)-2,2,2',2'-Tetramethyl-4α,4'β-bi[1,3-dioxolane]-5β-yl]ethane-1,2-diol is used as a starting material for the synthesis of new drugs. Its unique structure and stereochemistry make it a valuable tool in the development of innovative therapeutic agents with improved efficacy and selectivity.
Used in Chiral Catalysts:
The chiral nature of (R)-1-[(4R,4'R)-2,2,2',2'-Tetramethyl-4α,4'β-bi[1,3-dioxolane]-5β-yl]ethane-1,2-diol also makes it a potential candidate for use in chiral catalysis. As a chiral catalyst, it can be employed to control the stereochemistry of various chemical reactions, leading to the production of enantiomerically pure compounds with potential applications in the pharmaceutical, agrochemical, and fragrance industries.
Check Digit Verification of cas no
The CAS Registry Mumber 38145-93-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,1,4 and 5 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 38145-93:
(7*3)+(6*8)+(5*1)+(4*4)+(3*5)+(2*9)+(1*3)=126
126 % 10 = 6
So 38145-93-6 is a valid CAS Registry Number.
38145-93-6Relevant articles and documents
Zeolite catalyzed selective deprotection of di- and tri-O-isopropylidene sugar acetals
Bhaskar, Pallooru Muni,Mathiselvam, Manoharan,Loganathan, Duraikkannu
, p. 1801 - 1807 (2008/12/21)
H-Beta zeolite, a microporous solid acid, is demonstrated to be an efficient catalyst for the selective deprotection of cyclic as well as acyclic O-isopropylidene sugar acetals derived from d-glucose, d-xylose, d-mannose, and d-mannitol in aqueous MeOH at room temperature. A notable observation is the conversion of d-mannitol triacetonide into 1,2:3,4-di-O-isopropylidene-d-mannitol (48%) and 3,4-O-isopropylidene-d-mannitol (36%) brought about in 6 h by H-beta zeolite and the non-occurrence of any hydrolysis in the case of H-ZSM-5 catalyzed reaction in 24 h under the same conditions.
THE SYNTHESIS OF 1,2:5,6-DI-O-ISOPROPYLIDENE-D-MANNITOL: A COMPARATIVE STUDY
Kuszmann, Janos,Tomori, Eva,Meerwald, Ingrid
, p. 87 - 100 (2007/10/02)
Three different methods of acetonation of D-mannitol using (a) acetone and zinc chloride, (b) 2,2-dimethoxypropane, 1,2-dimethoxyethane, and tin(II)chloride, and (c) 2-methoxypropane, N,N-dimethylformamide, and p-toluenesulfonic acid were studied in detail and compared, using gas-liquid chromatographic techniques.In each reaction, isomeric diacetals are formed, but method a gives the 1,2:5,6-diacetal in the highest yield (63percent).Methods b and c give a more complex mixture of acetals than proposed in the literature, and both methods are less economical than a.A new 1,2:3,6:4,5-tri-O-isopropylidene-D-mannitol could be separated, and its graded hydrolysis was compared to that of the 1,2:3,4:5,6-triacetal.
REINVESTIGATION OF THE ACETALATION OF D-GLUCITOL WITH ACETONE-ZINC CHLORIDE
Kuszmann, Janos,Sohar, Pal,Horvath, Gyula,Tomori, Eva,Idei, Miklos
, p. 243 - 254 (2007/10/02)
The acetonation of D-glucitol in the presence of zinc chloride has been studied in detail by gas-liquid chromatographic techniques.From among the 12 different peaks, those belonging to the 1,2:3,4:5,6-tri-, 1,2:3,5:4,6-tri-, 3,4:5,6-di-, 2,3:5,6-di-, 1,2:3,4-di-, 1,2:5,6-di-, 1,2:4,6-di-, 1,2-mono-, 2,3-mono-, 3,4-mono-, and 5,6-mono-acetals could be identified.The course of the reaction was also studied by g.l.c.From the time dependent ratio of the different acetals, it could be concluded that the reaction is kinetically controlled at the beginning, when terminal acetals are mainly formed.In the thermodinamically controlled equilibrium, reached after 5 days, the 1,2:3,4:5,6-tri- and the 2,3:5,6-di-acetal are present in almost equal proportions.The structure of the (new) 1,2:3,5:4,6-triacetal was established by mass-spectrometric and 13C-n.m.r. investigation.
