38154-40-4

Basic information

• Product Name: 4-CHLORO-2-ETHYLQUINAZOLINE
• Synonyms: 4-CHLORO-2-ETHYLQUINAZOLINE
• CAS NO: 38154-40-4
• Molecular Formula: C₁₀H₉ClN₂
• Molecular Weight: 192.64
• Mol File: 38154-40-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 178℃
• Boiling Point: 231℃
• Flash Point: 116℃
• Appearance: /
• Density: 1.244
• Vapor Pressure: 0.096mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: 2-8°C
• PKA: 1.24±0.30(Predicted)
• CAS DataBase Reference: 4-CHLORO-2-ETHYLQUINAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-ETHYLQUINAZOLINE(38154-40-4)
• EPA Substance Registry System: 4-CHLORO-2-ETHYLQUINAZOLINE(38154-40-4)

Safety Data

• Hazardous Substances Data: 38154-40-4(Hazardous Substances Data)

Usage

General Description

4-Chloro-2-ethylquinazoline is a chemical compound with the molecular formula C10H9ClN2. This organic compound is a quinazoline derivative with a chloro group at the 4-position and an ethyl group at the 2-position of the quinazoline ring. It is used as a building block in the synthesis of pharmaceuticals and agrochemicals. This chemical may have potential applications in medicinal chemistry due to its quinazoline-based structure, which has been found to exhibit various biological activities. Additionally, it is important to handle this chemical with care as it may be hazardous if not used properly.

InChI:InChI=1/C10H9ClN2/c1-2-9-12-8-6-4-3-5-7(8)10(11)13-9/h3-6H,2H2,1H3

Upstream product

• 3137-64-2 2-ethyl-3H-quinazolin-4-one 
• 3137-64-2 2-Ethyl-quinazolin-4-ol 
• 19165-26-5 2-(propionylamino)benzoic acid 
• 118-92-3 anthranilic acid 
• 21411-14-3 propionamidobenzamide 

Relevant articles and documents

Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration

As a continuation of our structure-activity relationship (SAR) studies on 4-anilinoquinazolines as potent apoptosis inducers and to identify anticancer development candidates, we explored the replacement of the 2-Cl group in our lead compound 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (6b, EP128265, MPI-0441138) by other functional groups. This SAR study and lead optimization resulted in the identification of N-(4-methoxyphenyl)-N,2- dimethylquinazolin-4-amine (6h, EP128495, MPC-6827) as an anticancer clinical candidate. Compound 6h was found to be a potent apoptosis inducer with EC 50 of 2 nM in our cell-based apoptosis induction assay. It also has excellent blood brain barrier penetration, and is highly efficacious in human MX-1 breast and other mouse xenograft cancer models.