38170-37-5Relevant articles and documents
Group of isotope labeling reagents for carboxyl labeling and synthetic method thereof
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Paragraph 0028; 0029, (2017/09/01)
The invention provides a group of isotope labeling reagents for carboxyl labeling and a synthetic method thereof and belongs to the field of chemical synthesis. One end of an isotope labeling reagent is primary amine while the other end is trimethyl ammonium salt, and the primary amine and the trimethyl ammonium salt are connected through a plurality of carbon chains. The synthetic process comprises the following steps of: by taking N,N-dimethyl ethidene diamine and homologs thereof as a reaction raw material, protecting primary amino with di-tert-butyl dicarbonate ester ((BOC)2O); then performing a reaction with an iodomethane reagent containing isotopes D and 13C in an alkaline condition; and finally, removing the protecting group in an acidic condition to obtain a target product. A group of novel isotope labeling reagents capable of being used for efficiently labeling carboxyl are synthesized through nucleophilic substitution reaction, so that the reagents are low in price and simple to operate; and the analytical efficiency and accuracy can be remarkably improved after the isotope reagents obtained by the invention are used for labeling.