38175-34-7

Basic information

• Product Name: 4-(3'-Methoxyphenyl)-2-pyrrolidinone
• Synonyms: 4-(3'-Methoxyphenyl)-2-pyrrolidinone;2-Pyrrolidinone, 4-(3-Methoxyphenyl);4-(3-METHOXYPHENYL)PYRROLIDIN-2-ONE
• CAS NO: 38175-34-7
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol File: 38175-34-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 395.105 °C at 760 mmHg
• Flash Point: 192.753 °C
• Appearance: /
• Density: 1.129 g/cm³
• CAS DataBase Reference: 4-(3'-Methoxyphenyl)-2-pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3'-Methoxyphenyl)-2-pyrrolidinone(38175-34-7)
• EPA Substance Registry System: 4-(3'-Methoxyphenyl)-2-pyrrolidinone(38175-34-7)

Safety Data

• Hazardous Substances Data: 38175-34-7(Hazardous Substances Data)

Usage

General Description

4-(3'-Methoxyphenyl)-2-pyrrolidinone is a chemical compound that belongs to the class of pyrrolidinones. It is commonly used in organic synthesis and pharmaceutical research due to its potential pharmaceutical and therapeutic applications. 4-(3'-Methoxyphenyl)-2-pyrrolidinone is known for its ability to act as a versatile intermediate for the synthesis of various bioactive molecules and pharmaceutical drugs. Its chemical structure contains a pyrrolidinone ring with a 3'-methoxyphenyl substituent, which gives it unique chemical properties and reactivity. 4-(3'-Methoxyphenyl)-2-pyrrolidinone is considered an important building block for the development of new drug compounds and pharmacological agents.

Upstream product

• 591-31-1 3-methoxy-benzaldehyde 
• 372944-87-1 methyl 3-(3-methoxyphenyl)-4-nitrobutanoate 
• 38693-90-2 trans-3-(3-methoxyphenyl)acrylic acid methyl ester 

Downstream Products

• 1056971-34-6 N-benzyl-3-(3-methoxyphenyl)pyrrolidine 
• 38175-35-8 3-(3-methoxyphenyl)pyrrolidine 

Relevant articles and documents

Synthesis of 3-(3-hydroxyphenyl)pyrrolidine dopamine D3 receptor ligands with extended functionality for probing the secondary binding pocket

A series of 3-(3-hydroxyphenyl)pyrrolidine analogues which incorporate N-alkyl groups and N-butylamide-linked benzamide functionality have been synthesized and their in vitro binding affinities at human dopamine receptors have been evaluated. Our ligand design strategy was to take the 3-(3-hydroxyphenyl)pyrrolidine scaffold and extend functionality from the orthosteric binding site to the secondary binding pocket for enhancing affinity and selectivity for the D3 receptor. The N-alkyl analogues constitute a homologous series from N-pentyl to N-decyl to probe the length/bulk tolerance of the secondary binding pocket of the D3 receptor. Enantiomeric 3-(3-hydroxyphenyl)pyrrolidine analogues were also prepared in order to test the chirality preference of the orthosteric binding site for this scaffold. Benzamide analogues were prepared to enhance affinity and/or selectivity based upon the results of the homologous series.