38195-12-9

Basic information

• Product Name: (R)-1-formylethyl p-toluenesulfonate
• Synonyms: (R)-1-formylethyl p-toluenesulfonate
• CAS NO: 38195-12-9
• Molecular Weight: 228.269
• Mol File: 38195-12-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-1-formylethyl p-toluenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-formylethyl p-toluenesulfonate(38195-12-9)
• EPA Substance Registry System: (R)-1-formylethyl p-toluenesulfonate(38195-12-9)

Safety Data

• Hazardous Substances Data: 38195-12-9(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 74044-76-1 1,6-dideoxy-3,4-O-isopropylidene-D-mannitol 2,5-di-p-toluenesulfonate 
• 171524-74-6 1,6-dideoxy-D-mannitol 2,5-di-p-toluenesulfonate 

Downstream Products

• 1015479-72-7 dibenzyl (1S,2S)-1,2-epoxypropylphosphonate 
• 172585-28-3 dibenzyl (1R,2S)-1,2-epoxypropylphosphonate 

Relevant articles and documents

An efficient, one-pot synthesis of fosfomycin dialkyl esters from (R)-2-tosyloxypropanal

(R)-2-Tosyloxypropanal (4) was prepared from D-mannitol in a 7-step sequence (51% overall yield). Addition of dialkyl phosphonates to 4 in the presence of titanium isopropoxide and the subsequent treatment with DBU stereoselectively afforded, in one-pot, fosfomycin dimethyl (5a) and dibenzyl (5b) esters both in 58% isolated yield.

A convergent synthesis of optically active aspyrone

Aspyrone (1) was elaborated in an optically pure form by the key reaction involving a nucleophilic addition of δ-lactone enolate to 2-tosyloxyaldehyde and a subsequent in situ formation of epoxide.