382150-70-1

Basic information

• Product Name: 1,3-di-tert-butyl 2-(2-aminophenyl)propanedioate
• Synonyms: 1,3-di-tert-butyl 2-(2-aminophenyl)propanedioate
• CAS NO: 382150-70-1
• Molecular Weight: 307.39
• Mol File: 382150-70-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,3-di-tert-butyl 2-(2-aminophenyl)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-di-tert-butyl 2-(2-aminophenyl)propanedioate(382150-70-1)
• EPA Substance Registry System: 1,3-di-tert-butyl 2-(2-aminophenyl)propanedioate(382150-70-1)

Safety Data

• Hazardous Substances Data: 382150-70-1(Hazardous Substances Data)

Upstream product

• 1493-27-2 ortho-nitrofluorobenzene 
• 541-16-2 t-butyl malonate 
• 382150-69-8 di-tert-butyl 2-(2-nitrophenyl)malonate 

Downstream Products

• 59-48-3 2-oxoindole 
• 1437759-62-0 C₃₅H₄₈N₂O₄ 
• 1422035-97-9 1,3-di-tert-butyl 2-(2-{[1-(tert-butoxycarbonyl)azepane-4-yl]amino}phenyl)propanedioate 
• 1422035-95-7 1,3-di-tert-butyl 2-(2-{[1-(tert-butoxycarbonyl)azetidine-3-yl]amino}phenyl)propanedioate 

Relevant articles and documents

Synthesis of substituted t-butyl 3-alkyloxindole-3-carboxylates from di-t-butyl (2-nitrophenyl)malonates

Using a novel tandem reduction-cyclization, we synthesized t-butyl 3-alkyloxindole-3-carboxylates from the di-t-butyl 2-alkyl-2-(2-nitrophenyl)malonate. Introduction of an α-substituent to the di-t-butyl 2-(2-nitrophenyl)-malonates and addition of acid promoted reactivity. This methodology was successfully applied to gram-scale-synthesis of the t-butyl 3-methyloxindole-3-carboxylate 1 and 3-hydroxymethyl-3-methyloxindole 2 without silica gel column chromatography.

Synthesis and pharmacological characterization of novel inverse agonists acting on the viral-encoded chemokine receptor US28

G-protein coupled receptors encoded by viruses represent an unexplored class of potential drug targets. In this study, we describe the synthesis and pharmacological characterization of the first class of inverse agonists acting on the HCMV-encoded receptor US28. It is shown that replacement of the 4-hydroxy group of lead compound 1 with a methylamine group results in a significant 6-fold increase in affinity. Interestingly, increasing the rigidity of the spacer by the introduction of a double bond also leads to a significant increase in binding affinity compared to 1. These novel inverse agonists serve as valuable tools to elucidate the role of constitutive signaling in the pathogenesis of viral infection and may have therapeutic potential as leads for new antiviral drugs.

A short and efficient synthesis of N-substituted indol-2-ones (oxindoles)

A short and high yielding process has been developed for the synthesis of N-(4-piperidinyl)-indol-2-ones. This strategy also constitutes a general route to N-substituted indol-2-ones.