383-70-0

Basic information

• Product Name: N-(Trifluoroacetyl)glycine
• Synonyms: TRIFLUOROACETYL GLYCINE;n-(trifluoroacetyl)glycine;N-ALPHA-TRIFLUOROACETYL-GLYCINE;TFA-GLYCINE;TFA-GLY-OH;[(Trifluoroacetyl)amino]acetic acid;glycine,N-(trifluoroacetyl)-;N-alpha-Trifluoracetyl-glycin
• CAS NO: 383-70-0
• Molecular Formula: C₄H₄F₃NO₃
• Molecular Weight: 171.07
• Product Categories: Amino Acids;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives
• Mol File: 383-70-0.mol
• Article Data: 24

Chemical Properties

• Melting Point: 120-121 °C
• Boiling Point: 291.6°C
• Flash Point: 130°C
• Appearance: white solid
• Density: 1.534
• Vapor Pressure: 0.000479mmHg at 25°C
• Refractive Index: 1.386
• Storage Temp.: 2-8°C
• Solubility: Chloroform, DMSO
• PKA: 2.99±0.10(Predicted)
• CAS DataBase Reference: N-(Trifluoroacetyl)glycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(Trifluoroacetyl)glycine(383-70-0)
• EPA Substance Registry System: N-(Trifluoroacetyl)glycine(383-70-0)

Safety Data

• Hazardous Substances Data: 383-70-0(Hazardous Substances Data)

Usage

Description

N-(Trifluoroacetyl)glycine, with the CAS number 383-70-0, is a white solid compound that is primarily utilized in the field of organic synthesis. It is known for its unique chemical properties that make it a valuable component in various chemical reactions and processes.

Uses

Used in Organic Synthesis:
N-(Trifluoroacetyl)glycine is used as a synthetic building block for the creation of a wide range of organic compounds. Its application in this field is due to its ability to participate in various chemical reactions, such as condensation, substitution, and rearrangement, which are essential for the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-(Trifluoroacetyl)glycine is used as an intermediate in the synthesis of various drugs and drug candidates. Its unique chemical properties allow it to be a key component in the development of new medications, contributing to the advancement of pharmaceutical research and drug discovery.
Used in Chemical Research:
N-(Trifluoroacetyl)glycine is also employed as a research tool in the field of chemistry. It is used to study the properties and behavior of various chemical reactions, providing valuable insights into the mechanisms and pathways involved. This helps researchers to better understand the underlying principles of organic chemistry and to develop new strategies for the synthesis of complex molecules.
Used in Material Science:
In the field of material science, N-(Trifluoroacetyl)glycine is used as a component in the development of novel materials with specific properties. Its unique chemical structure allows it to be incorporated into the design of new materials, such as polymers, coatings, and composites, which can be tailored for various applications, including electronics, aerospace, and automotive industries.

InChI:InChI=1/C4H4F3NO3/c5-4(6,7)3(11)8-1-2(9)10/h1H2,(H,8,11)(H,9,10)

Upstream product

• 383-64-2 S-ethyl trifluoroacetate 
• 56-40-6 glycine 
• 500-73-2 phenyl trifluoroacetate 
• 407-25-0 trifluoroacetic anhydride 
• 383-63-1 ethyl trifluoroacetate, 
• 848860-95-7 S-dodecyl trifluorothioacetate 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 354-32-5 trifluoracetyl chloride 

Downstream Products

• 16975-16-9 N^α-Trifluoracetyl-glycin-hydroxymsaeure-benzylester 
• 20781-35-5 N-Trifluoracetyl-glycin-(2.4-dimethoxy-benzyl-amid) 
• 3799-57-3 N-(N-Trifluoracetyl-glycyl)-L-phenylalanin-tert.-butylester 
• 20781-36-6 N-Trifluoracetyl-glycin-(2,4,6-Trimethoxy-benzylamid) 
• 856-43-9 N-Trifluoracetyl-glycyl-S-benzyl-L-cystein-methylester 
• 16561-93-6 N-trifluoroacetyl-glycine 3-oxo-2-trityl-isoxazolidin-4-ylamide 
• 5879-48-1 N-Trifluoracetyl-glycyl-glycin-<2-methylmercapto-ethylester> 
• 90476-41-8 [(2-{Benzyl-[2-(2,2,2-trifluoro-acetylamino)-acetyl]-amino}-2-methyl-propionylamino)-methyl]-phosphonic acid diethyl ester 
• 82706-23-8 (E)-But-2-en-1-yl 2-(2,2,2-trifluoroacetamido)acetate 
• 142370-00-1 ((C₆H₅)3P)2Pt(CF₃C(O)NCH₂COO) 
• 3397-30-6 2-(2,2,2-trifluoroacetamido)acetic acid succinimidyl ester 
• 752253-28-4 2,4,6-Triiodo-5-{methyl[2-(2,2,2-trifluoroacetylamino)-acetyl]amino}-isophthalic acid dichloride 
• 752253-20-6 2,4,6-triiodo-5-[2-(2,2,2-trifluoroacetylamino)-acetylamino]-isophthalic acid dichloride 
• 1202396-25-5 C₃₀H₂₉F₃N₂O₇ 

Relevant articles and documents

N-TFA-Gly-Bt-based stereoselective synthesis of substituted 3-amino tetrahydro-2 h-pyran-2-ones via an organocatalyzed cascade process

Chiral-substituted 3-amino tetrahydro-2H-pyran-2-ones were prepared in excellent enantioselectivities (up to 99percent ee) via an organo-catalyzed cascade procedure with N-TFA-Gly-Bt and α,β-unsaturated aldehydes as the substrates. The corresponding tetra

BF3·OEt2-TFAA Mediated Tetra-Functionalization of Amino Acids-Synthesis of Di-and Tri-Substituted 2-Trifluoromethyl Oxazoles in One Pot

A highly efficient, TFAA-BF3·OEt2 mediated multicomponent coupling of amino acid, TFAA, and aromatics provides a broad library of 2-Trifluoromethyl equipped 2,5-disubstituted/2,4,5-Trisubstituted oxazoles or N-(trifluoroacetyl)-β-Aminoalkyl ketones. This amino acid tetra-functionalization approach involves amidation (C-N), anhydride (C-O), Friedel-Crafts acylation (C-C), and Robinson-Gabriel annulation (C-O) followed by dehydrative aromatization. This reaction takes place under operationally simple, mild, and metal-free conditions using readily available amino acids and aromatic compounds.

SYNTHESIS OF (2S,3R,4R)-4,5-DIHYDROXYISOLEUCINE AND DERIVATIVES

The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diastereomer mix by acylase, and subsequent Sharpless dihydroxylation of the resulting 2-amino-3-methylpent-4-enoicacid derivative.