383-72-2

Basic information

• Product Name: (Trifluoroacetylamino)acetic acid methyl ester
• Synonyms: (Trifluoroacetylamino)acetic acid methyl ester;N-(Trifluoroacetyl)glycine methyl ester
• CAS NO: 383-72-2
• Molecular Formula: C₅H₆F₃NO₃
• Molecular Weight: 185.1012
• Mol File: 383-72-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 214.53°C (rough estimate)
• Flash Point: 67.3°C
• Appearance: /
• Density: 1.352g/cm³
• Vapor Pressure: 0.623mmHg at 25°C
• Refractive Index: 1.371
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (Trifluoroacetylamino)acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (Trifluoroacetylamino)acetic acid methyl ester(383-72-2)
• EPA Substance Registry System: (Trifluoroacetylamino)acetic acid methyl ester(383-72-2)

Safety Data

• Hazardous Substances Data: 383-72-2(Hazardous Substances Data)

Usage

Description

(Trifluoroacetylamino)acetic acid methyl ester, with the molecular formula C6H6F3NO3, is a methyl ester derivative of (trifluoroacetylamino)acetic acid. It features a trifluoroacetyl group and an amino group, making it a versatile compound in the realm of organic synthesis and chemical research.

Uses

Used in Pharmaceutical Industry:
(Trifluoroacetylamino)acetic acid methyl ester is used as a building block for the synthesis of various pharmaceuticals. Its unique chemical structure and reactivity contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (Trifluoroacetylamino)acetic acid methyl ester is utilized as a starting material for the creation of novel compounds with pesticidal, herbicidal, or other agricultural applications, enhancing crop protection and yield.
Used in Chemical Research:
(Trifluoroacetylamino)acetic acid methyl ester serves as a reagent in the preparation of complex organic molecules, facilitating advancements in chemical research and the discovery of new chemical entities.
Used in Biochemical Studies:
Due to its versatile chemical structure, (Trifluoroacetylamino)acetic acid methyl ester may also find applications in biochemical studies, potentially aiding in the understanding of biological processes and the development of targeted therapies.

InChI:InChI=1/C5H6F3NO3/c1-12-3(10)2-9-4(11)5(6,7)8/h2H2,1H3,(H,9,11)

Upstream product

• 431-47-0 trifluoroacetic acid-methyl ester 
• 616-34-2 methoxycarbonylmethylamine 
• 67-56-1 methanol 
• 6000-43-7 2-aminoethanoic acid hydrochloride 
• 56-40-6 glycine 
• 407-25-0 trifluoroacetic anhydride 
• 1613110-96-5 lipodiscamide A 
• 1613110-97-6 lipodiscamide B 
• 354-38-1 2,2,2-trifluoroacetamide 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 4525-28-4 methyl (E)-3-methoxybut-2-enoate 
• 60456-20-4 (E)-methyl 3-methoxy-3-phenylprop-2-enoate 
• 40203-51-8 (Z)-methyl 3-methoxy-3-phenylprop-2-enoate 
• 107940-27-2 N-(Trifluoracetyl)-N-(trimethylsilyl)glycin-methylester 

Relevant articles and documents

Single Electron Transfer-Induced Selective α-Oxygenation of Glycine Derivatives

Modification of amino acids is an important strategy in organic and bioorganic chemistry. In contrast to common side-chain functionalization, backbone modification is much less explored. Especially glycine units seem to be attractive and versatile since a wide range of functionality can be potentially introduced. We report here oxidative modification of glycinates that are stable and enable further functionalization. Selective glycinate enolate oxidation by TEMPO or a FeCp2PF6/TEMPO reagent combination provides stable alkoxyamines in good to excellent yields. The methodology is expanded to glycine-containing dipeptides demonstrating selective oxygenation at the glycine unit. The orthogonal reactivity potential of oxygenated glycines for transformation to other amino acid derivatives is explored.

Lipodiscamides A-C, new cytotoxic lipopeptides from discodermia kiiensis

Lipodiscamides A-C, three new lipodepsipeptides, were characterized from the marine sponge Discodermia kiiensis. These structurally rare cyclic lipodepsipeptides were found to possess an unprecedented dilactone macrocycle and, thus, represent a new family of lipopeptides. They are the only lipopeptides bearing 4S-hydroxy-trans-2-enoate, and noncanonical amino acids, l-3-ureidoalanine (Uda), E-dehydronorvaline (Denor), and d-citrulline (Cit). MTT assays against P388 and HeLa cells revealed the moderate cytotoxicity of all three compounds.

N-Trifluoroacetyl amino acids. XIX. Gas chromatographic separation of N-TFA-dipeptide methyl esters.

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