38310-90-6 Usage
Description
11BETA-PROSTAGLANDIN E2, also known as 11β-PGE2, is a C-11 epimer of PGE2, a type of prostaglandin. It is a bioactive lipid compound that plays a significant role in various physiological processes, including inflammation, pain, and fever. 11BETA-PROSTAGLANDIN E2 exhibits moderate inhibitory effects on PGE2 binding to rat hypothalamic membranes and the prostaglandin transporter protein.
Uses
Used in Pharmaceutical Applications:
11BETA-PROSTAGLANDIN E2 is used as a moderate inhibitor for [application reason] PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM. This property makes it a potential candidate for the development of drugs targeting prostaglandin-related pathways in various diseases and conditions.
Used in Bone Resorption Studies:
11BETA-PROSTAGLANDIN E2 is used as a stimulator for [application reason] bone resorption in rats at concentrations of 10-8 to 10-6 M, which is similar to PGE2. This application can be valuable in studying the mechanisms of bone resorption and developing treatments for bone-related disorders.
Used in Prostaglandin Transporter Inhibition:
11BETA-PROSTAGLANDIN E2 is used as an inhibitor for [application reason] PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM. This application can be useful in understanding the role of prostaglandin transporters in various physiological processes and developing targeted therapies for related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 38310-90-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,3,1 and 0 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 38310-90:
(7*3)+(6*8)+(5*3)+(4*1)+(3*0)+(2*9)+(1*0)=106
106 % 10 = 6
So 38310-90-6 is a valid CAS Registry Number.
38310-90-6Relevant articles and documents
Preparation of ent-prostaglandin E2
Taber, Douglass F,Jiang, Qin
, p. 5991 - 5994 (2007/10/03)
The enantiomeric prostaglandins, exemplified by ent-PGE2, are apparently produced in vivo by the nonenzymatic oxidation of arachidonic acid. To assess the physiological activity of ent-PGE2, it was necessary to prepare it by total sy
Isolation of a new naturally occurring prostaglandin, 5-trans-PGA 2 . Synthesis of 5-trans-PGE 2 and 5-trans-PGF 2a .
Bundy,Daniels,Lincoln,Pike
, p. 2124 - 2124 (2007/10/06)
-
Enzymatic preparation and purification of prostaglandin E2.
Lapidus,Grant,Alburn
, p. 371 - 373 (2007/10/16)
An enzymatic system has been developed for the production of prostaglandin E(2) (PGE(2)) from arachidonic acid by extracts of sheep seminal vesicular glands. The presence of glutathione insures high yields. A new procedure for the purification of PGE(2) was also developed, based on the dialysis of the biosynthesized product at pH 8 and extraction of the dialysate at pH 3 with chloroform. This procedure routinely gives yields of PGE(2) of 25-37% (from arachidonic acid) with a purity of 90-100%. Additional analytical proof of the identity of PGE(2) was provided by physicochemical characteristics of the crystalline thiosemicarbazide derivative, which can be readily prepared under mild conditions.
