383131-08-6 Usage
Description
2-[3-(TRIFLUOROMETHYL)PHENYL]AZEPANE is a heterocyclic chemical compound with the molecular formula C14H15F3N. It belongs to the azepane class and features a trifluoromethyl-substituted phenyl ring. 2-[3-(TRIFLUOROMETHYL)PHENYL]AZEPANE is known for its unique structural and physicochemical properties, which make it a promising candidate for pharmaceutical research and drug development. The presence of the azepane ring and the fluorinated moiety in its structure contribute to its potential as a valuable scaffold for designing bioactive molecules targeting specific biological pathways.
Uses
Used in Pharmaceutical Research and Drug Development:
2-[3-(TRIFLUOROMETHYL)PHENYL]AZEPANE is used as a potential candidate for the development of novel drugs due to its distinct structure and the presence of a trifluoromethyl group. This allows it to target specific biological pathways and exhibit unique biological activities, making it a valuable scaffold for designing bioactive molecules.
Used in Medicinal Chemistry:
The synthesis and characterization of 2-[3-(TRIFLUOROMETHYL)PHENYL]AZEPANE contribute to the exploration and understanding of fluorinated compounds in medicinal chemistry. Its unique properties and potential applications make it an important compound for further research and development in the field.
Check Digit Verification of cas no
The CAS Registry Mumber 383131-08-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,8,3,1,3 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 383131-08:
(8*3)+(7*8)+(6*3)+(5*1)+(4*3)+(3*1)+(2*0)+(1*8)=126
126 % 10 = 6
So 383131-08-6 is a valid CAS Registry Number.
383131-08-6Relevant articles and documents
Discovery, synthesis and exploration of N-benzylsulfonyl-2-phenylazepanes as inhibitors of Bim expression in a mouse embryonic fibroblast model
Abbott, Belinda M.,Dahanayake, Darani,Glab, Jason A.,Mbogo, George W.,Puthalakath, Hamsa,Richards, Benjamin J.,Smith, Brian J.
, (2022/02/07)
Chronic activation of beta-adrenergic receptors by the sympathetic nervous system results in the apoptosis of cardiomyocytes. Due to the inability of cardiomyocytes to regenerate, this can result in heart failure. Upregulation of the pro-apoptotic protein Bim has been implicated as the cause of cardiomyocyte apoptosis. Beta blockers are the frontline drug used to negate this apoptotic pathway, as no direct inhibitors of Bim expression currently exist. Unfortunately, treatment of heart failure using beta blockers is not optimal. Therefore, direct inhibition of Bim expression is an attractive strategy to provide protection against stress-induced apoptosis of cardiomyocytes. Herein we explore a class of N-benzylsulfonyl-2-phenylazepanes to obtain anti-apoptotic compounds capable of reducing Bim expression levels to 7% of the control at 10 μM in cardiomyocytes under conditions of chronic beta-adrenergic receptor activation with little inhibitory effect upon protein kinase A activity and minimal toxicity.
