38316-05-1

Basic information

• Product Name: 4-methoxy-alpha-(nitromethyl)benzyl alcohol
• Synonyms: 4-methoxy-alpha-(nitromethyl)benzyl alcohol;1-(4-methoxyphenyl)-2-nitroethanol;4-Methoxy-α-(nitromethyl)benzenemethanol;4-Methoxy-α-nitromethylbenzenemethanol;α-(Nitromethyl)-4-methoxybenzenemethanol;2-Nitro-1-(4-methoxyphenyl)ethanol
• CAS NO: 38316-05-1
• Molecular Formula: C₉H₁₁NO₄
• Molecular Weight: 197.18794
• EINECS: 253-877-9
• Mol File: 38316-05-1.mol
• Article Data: 96

Chemical Properties

• Melting Point: 40-41℃
• Boiling Point: 365.9 °C at 760 mmHg
• Flash Point: 175.1 °C
• Appearance: /
• Density: 1.253±0.06 g/cm3 (20 ºC 760 Torr)
• PKA: 8.01±0.38(Predicted)
• CAS DataBase Reference: 4-methoxy-alpha-(nitromethyl)benzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-alpha-(nitromethyl)benzyl alcohol(38316-05-1)
• EPA Substance Registry System: 4-methoxy-alpha-(nitromethyl)benzyl alcohol(38316-05-1)

Safety Data

• Hazardous Substances Data: 38316-05-1(Hazardous Substances Data)

Upstream product

• 124-41-4 sodium methylate 
• 123-11-5 4-methoxy-benzaldehyde 
• 51146-35-1 trimethylsilyl ester of aci-nitromethane 
• 105-13-5 4-Methoxybenzyl alcohol 
• 100-09-4 4-methoxybenzoic acid 
• 10364-93-9 1-(4-methoxybenzoyl)-imidazole 
• 46318-58-5 4-methoxybenzoylnitromethane 
• 75-52-5 nitromethane 
• 563-70-2 bromonitromethane 
• 37687-57-3 2-chloro-3-hydroxy-4-methoxybenzaldehyde 

Downstream Products

• 7099-91-4 p-methoxybenzoylformic acid 
• 3179-10-0 (E)-1-methoxy-4-(2-nitrovinyl)benzene 
• 675579-61-0 (R)-1-(4-methoxyphenyl)-2-nitroethanol 
• 3179-10-0 1-methoxy-4-(2-nitro-vinyl)-benzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 58734-14-8 4-methoxy-N-tosylbenzamide 
• 1336918-24-1 (R)-1-(4-methoxyphenyl)-2-nitroethyl acetate 
• 1609166-89-3 C₁₇H₁₉NO₅ 

Relevant articles and documents

-

-

Highly efficient nanosized mesoporous CuMgAl ternary oxide catalyst

Highly efficient nanosized mesoporous CuMgAl ternary oxide catalysts are provided.

Revisit to Henry reaction by non conventional heterogeneous and efficient catalyst for nitroalcohol synthesis

A sustainable, green and efficient process for the synthesis of 2-nitro alcohol derivatives from different substituted aromatic aldehydes with nitroalkane by stirring at ambient temperature with high product yield is reported. Adoption of very mild reaction conditions, use of Calcined Eggshell (CES) as natural catalyst and simple workup are expected to contribute to the development of environmentally benign synthetic method for Henry (nitroaldol) reaction. CES is ecologically safe, inexpensive, and attractive heterogeneous base catalyst obtained from renewable resources, thus opening a new perspective for this process. Graphical abstract: [Figure not available: see fulltext.]

Metal-Free Deoxygenation of Chiral Nitroalkanes: An Easy Entry to α-Substituted Enantiomerically Enriched Nitriles

A metal-free, mild and chemodivergent transformation involving nitroalkanes has been developed. Under optimized reaction conditions, in the presence of trichlorosilane and a tertiary amine, aliphatic nitroalkanes were selectively converted into amines or nitriles. Furthermore, when chiral β-substituted nitro compounds were reacted, the stereochemical integrity of the stereocenter was maintained and α-functionalized nitriles were obtained with no loss of enantiomeric excess. The methodology was successfully applied to the synthesis of chiral β-cyano esters, α-aryl alkylnitriles, and TBS-protected cyanohydrins, including direct precursors of four active pharmaceutical ingredients (ibuprofen, tembamide, aegeline and denopamine).