383428-73-7

Basic information

• Product Name: 3-((α)‐2‐(2‐(6‐chloropyrimidin-4‐yl)oxy)phenyl)methyl-3-methoxyacrylate
• Synonyms: 3-((α)‐2‐(2‐(6‐chloropyrimidin-4‐yl)oxy)phenyl)methyl-3-methoxyacrylate
• CAS NO: 383428-73-7
• Molecular Weight: 320.732
• Mol File: 383428-73-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-((α)‐2‐(2‐(6‐chloropyrimidin-4‐yl)oxy)phenyl)methyl-3-methoxyacrylate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((α)‐2‐(2‐(6‐chloropyrimidin-4‐yl)oxy)phenyl)methyl-3-methoxyacrylate(383428-73-7)
• EPA Substance Registry System: 3-((α)‐2‐(2‐(6‐chloropyrimidin-4‐yl)oxy)phenyl)methyl-3-methoxyacrylate(383428-73-7)

Safety Data

• Hazardous Substances Data: 383428-73-7(Hazardous Substances Data)

Upstream product

• 1193-21-1 4,6-dichloropyrimidine 
• 77-78-1 dimethyl sulfate 
• 40800-90-6 3-(α-methoxy)methylene benzofuran-2-(3H)-ketone 
• 124-41-4 sodium methylate 
• 553-86-6 benzofuran-2(3H)-one 
• 614-75-5 2-Hydroxyphenylacetic acid 
• 125808-20-0 methyl 2-(2-hydroxyphenyl)-3-methoxyacrylate 
• 143230-42-6 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3,3-dimethoxypropionic acid methyl ester 

Downstream Products

• 131860-97-4 (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxy-propenoate 
• 475479-10-8 C₁₆H₁₆N₂O₅ 
• 143230-42-6 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3,3-dimethoxypropionic acid methyl ester 
• 915410-75-2 C₂₅H₂₁ClN₄O₅ 

Relevant articles and documents

[(6 - Substituted - pyrimidine -4 - oxyacetyl) phenyl] -3 - methoxy methyl acrylate (by machine translation)

The invention has the activity of inhibiting crop bacteria [(6 - substituted - pyrimidine - 4 - oxyacetyl) phenyl] - 3 - methoxy methyl acrylate, relates to the technical field of biochemistry. It has the following general structure: It is inhibiting the cucumber wilt disease, peanut pinguis bacteria, germ, galenical wheat, maize leaf spot, watermelon anthrax bacteria, donor bacteria and other applications has good activity. (by machine translation)

Preparation method of azoxystrobin

The invention discloses a preparation method of azoxystrobin. The preparation method of the azoxystrobin particularly comprises the following steps: performing reaction on hydroxyphenylacetic acid serving as a starting material and trimethyl orthoformate to generate 3-(alpha-methoxy)-methylene benzofuran-2-(3 hydrogen)-ketone, performing reaction on 3-(alpha-methoxy)-methylene benzofuran-2-(3 hydrogen)-ketone, sodium methylate and 4,6-dichloropyrimidine to obtain 3-((alpha)-2-(2-(6-chloropyrimidine-4-yl oxy)phenyl)-methyl 3-methoxyacrylate, performing reaction on 3-((alpha)-2-(2-(6-chloropyrimidine-4-oxy)phenyl)-methyl 3-methoxyacrylate, methanesulfonic acid and methylbenzene to obtain (E)-2-(2-(6-chloropyrimidine-4-yl oxy)phenyl)-methyl 3-methoxyacrylate, and finally performing reaction on (E)-2-(2-(6-chloropyrimidine-4-yl oxy)phenyl)-methyl 3-methoxyacrylate, hydroxybenzonitrile, potassium carbonate, ferric oxide and the like to obtain the azoxystrobin. According to the preparation method provided by the invention, the reaction process is easy to control and the yield of the prepared product is high.

PREPARATION METHOD FOR ACRYLATE COMPOUND

The present invention relates to a method for preparing an acrylate compound. The acrylate compound has a structure as shown in formula (I). The method includes: subjecting a compound with a structure of formula (II) or a mixture of compounds with structures of formula (I) and formula (II), and a catalyst to a contact reaction in the absence of an anhydride, and removing the resulting methanol by pressure reduced distillation during the contact reaction process. In the formulas (I) and (II), R is selected from one of: an alkoxy with a carbon number of 1-5, a substituent-containing phenoxyl with a carbon number of 6-20, a substituent-containing heteroaryloxy with a carbon number of 4-20, a substituent-containing heteroaryloxymethyl with a carbon number of 4-20, a substituent-containing phenoxymethyl with a carbon number of 5-20, and a substituent-containing alkyl with a carbon number of 2-20. According to the method for preparing an acrylate compound provided in the invention, the conversion rate and selectivity of the reaction can be substantially improved.