38353-09-2 Usage
Description
2-Hydroxypyrimidine hydrochloride is a light yellow to beige crystalline solid that serves as a crucial reagent in the synthesis of various pharmaceutical compounds. It is an essential component in the development of medications targeting specific diseases and conditions.
Uses
Used in Pharmaceutical Industry:
2-Hydroxypyrimidine hydrochloride is used as a reagent for the synthesis of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor. 2-Hydroxypyrimidine hydrochloride demonstrates improved potency for the potential treatment of chronic hepatitis C virus infection, making it a valuable asset in the fight against this debilitating disease.
Check Digit Verification of cas no
The CAS Registry Mumber 38353-09-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,3,5 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 38353-09:
(7*3)+(6*8)+(5*3)+(4*5)+(3*3)+(2*0)+(1*9)=122
122 % 10 = 2
So 38353-09-2 is a valid CAS Registry Number.
InChI:InChI=1/C4H4N2O.ClH/c7-4-5-2-1-3-6-4;/h1-3H,(H,5,6,7);1H
38353-09-2Relevant articles and documents
Novel and efficient synthesis of 2-aminooxazoles from pyrimidin-2(1H)-one
Alifanov, Vadim L.,Babaev, Eugene V.
, p. 263 - 270 (2007/10/03)
Stepwise conversion of pyrimidin-2(1H)-one to 2-amino-5-aryloxazoles via oxazolo[3,2-a]pyrimidinium salts is reported. The sequence involves, (i) regioselective N-alkylation of pyrimidone by phenacyl bromides, (ii) cyclization of obtained 1-(2-aryl-2-oxoethyl)pyrimidin-2(1H)-ones into oxazolo[3,2-a] pyrimidinium salts under the action of fuming sulfuric (or triflic) acid, and (iii) reaction of the obtained salts with hydrazine leading to 2-amino-5-aryloxazoles. Georg Thieme Verlag Stuttgart.
O-Alkyl-O-pyrimidin (2)yl-thionophosphonic acid esters
-
, (2008/06/13)
O-Alkyl-O-pyrimidin(2)yl-thionophosphonic acid esters of the formula STR1 in which R is alkyl with 1 to 6 carbon atoms, R' is alkyl with 1 to 6 carbon atoms or phenyl, R" and RIV each independently is hydrogen or alkyl with 1 to 4 carbon atoms, and R'" is halogen or hydrogen. Which possess insecticidal, acaricidal and nematocidal properties.