38367-40-7

Basic information

• Product Name: 2-CHLORO-1-PHENYL-1H-INDOLE-3-CARBALDEHYDE
• Synonyms: 2-CHLORO-1-PHENYL-1H-INDOLE-3-CARBALDEHYDE;2-chloro-1-phenyl-3-indolecarboxaldehyde;2-chloro-1-phenyl-indole-3-carbaldehyde;2-chloro-1-phenylindole-3-carbaldehyde
• CAS NO: 38367-40-7
• Molecular Formula: C₁₅H₁₀ClNO
• Molecular Weight: 255.699
• Mol File: 38367-40-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 324.9°C at 760 mmHg
• Flash Point: 150.3°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0.000238mmHg at 25°C
• Refractive Index: 1.631
• CAS DataBase Reference: 2-CHLORO-1-PHENYL-1H-INDOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-1-PHENYL-1H-INDOLE-3-CARBALDEHYDE(38367-40-7)
• EPA Substance Registry System: 2-CHLORO-1-PHENYL-1H-INDOLE-3-CARBALDEHYDE(38367-40-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 38367-40-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H10ClNO/c16-15-13(10-18)12-8-4-5-9-14(12)17(15)11-6-2-1-3-7-11/h1-10H

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 5059-30-3 2-chloroindole-3-carboxaldehyde 
• 98-80-6 phenylboronic acid 
• 122-39-4 diphenylamine 
• 5428-43-3 2-chloro-N,N-diphenylacetamide 
• 3335-98-6 1-phenyl-1,3-dihydro-indol-2-one 

Downstream Products

• 70500-34-4 2-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-1-phenyl-indole-3-carbaldehyde 
• 172869-56-6 methyl 8-phenylthieno[2,3-b]indole-2-carboxylate 
• 1174929-06-6 4-(2-chloro-1-phenyl-1H-indole-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 1093860-94-6 C₂₃H₁₇N 
• 1093860-96-8 C₂₄H₁₉NO 
• 1093860-95-7 C₂₈H₁₉N 
• 648432-24-0 7-phenyl-7H-benzo[c]carbazole 
• 54778-22-2 2-chloro-1-phenyl-indole-3-carboxylic acid 
• 63925-77-9 1-phenyl-2-piperazin-1-yl-indole-3-carbaldehyde 
• 847801-52-9 1-phenyl-2-(thiomorphin-4-yl)-1H-indole-3-carboxaldehyde 
• 120110-26-1 2-Chloro-1-phenyl-1H-indole-3-carbaldehyde O-(2,4-dinitro-phenyl)-oxime 
• 126177-50-2 2-Amino-1-phenyl-1H-indole-3-carbaldehyde 

Relevant articles and documents

Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors

Selective inhibition of the aspartyl protease renin has gained attraction as an interesting approach to control hypertension and associated cardiovascular risk factors given its unique position in the renin-angiotensin system. Using a combination of high-throughput screening, parallel synthesis, X-ray crystallography and structure-based design, we identified and optimized a novel series of potent and non-chiral indole-3-carboxamides with remarkable potency for renin. The most potent compound 5k displays an IC50 value of 2 nM.

Synthesis and antimicrobial activities of some imidazole substituted indoles

The compounds 1-substituted 2-(imidazol-1-yl)-3-(4,5-diarylimidazol-2-yl) indoles 2, 1-substituted 2-(imidazol-1-yl)-3-(phenanthro[9,10-d]imidazol-2-yl) indoles 3 and 1-substituted 2-(imidazol-1-yl)-3-(benzimidazol-2-yl)indoles 4 have been synthesized from 1-substituted 2-(imidazol-1-yl)-3-formylindole 1. The structural elucidation of the synthesised compounds has been performed by IR, 1H NMR and mass spectroscopic data and elemental analyses. Antimicrobial activities of the compounds are examined and notable antifungal activity is obtained from some of the compounds as expected in comparison with the control agent ketoconazole.

Condensated indoles from 2-chloroindole-3-aldehydes

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