38382-35-3

Basic information

• Product Name: N-(3-tert-butylphenyl)acetamide
• Synonyms: N-(3-tert-butylphenyl)acetamide
• CAS NO: 38382-35-3
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.26948
• Mol File: 38382-35-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 93-94.5 °C
• Boiling Point: 327.2±21.0 °C(Predicted)
• Appearance: /
• Density: 1.010±0.06 g/cm3(Predicted)
• PKA: 15.12±0.70(Predicted)
• CAS DataBase Reference: N-(3-tert-butylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-tert-butylphenyl)acetamide(38382-35-3)
• EPA Substance Registry System: N-(3-tert-butylphenyl)acetamide(38382-35-3)

Safety Data

• Hazardous Substances Data: 38382-35-3(Hazardous Substances Data)

Upstream product

• 7463-31-2 3-Acetamidoacetophenone 
• 75-24-1 trimethylaluminum 
• 507-20-0 tertiary butyl chloride 
• 103-84-4 Acetanilid 
• 3282-30-2 pivaloyl chloride 
• 5369-19-7 3-tert-butylaniline 
• 108-24-7 acetic anhydride 

Downstream Products

• 918445-56-4 5-tert-butyl-2-chlorophenylamine 
• 68176-57-8 4-(tert-butyl)-1,2-diaminobenzene 
• 142564-53-2 5-(tert-butyl)-2-nitroaniline 
• 109774-65-4 Acetyl-(3-tert-butyl-phenyl)-carbamic acid tert-butyl ester 
• 70634-29-6 acetic acid-(3-tert-butyl-4-nitro-anilide) 
• 6933-55-7 acetic acid-(5-tert-butyl-2-nitro-anilide) 

Relevant articles and documents

Regiodivergent C?H and Decarboxylative C?C Alkylation by Ruthenium Catalysis: ortho versus meta Position-Selectivity

Ruthenium(II)biscarboxylate complexes enabled the selective alkylation of C?H and C?C bonds at the ortho- or meta-position. ortho-C?H Alkylations were achieved with 4-, 5- as well as 6-membered halocycloalkanes. Furthermore, the judicious choice of the directing group allowed for a full control of ortho-/meta-selectivities. Detailed mechanistic studies by experiment and computation were performed and provided strong support for an oxidative addition/reductive elimination process for ortho-alkylations, while a homolytic C?X cleavage was operative for the meta-selective transformations.

Access to "friedel-Crafts-Restricted" tert -alkyl aromatics by activation/methylation of tertiary benzylic alcohols

Herein we describe a two-step protocol to prepare m-tert-alkylbenzenes. The appropriate tertiary benzylic alcohols are activated with SOCl2 or concentrated HCl and then treated with trimethylaluminum, affording the desired products in 68-97% yields (22 examples). This reaction sequence is successful in the presence of a variety of functional groups, including acid-sensitive and Lewis-basic groups. In addition to t-Bu groups, 1,1-dimethylpropyl and 1-ethyl-1-methylpropyl groups can also be installed using this method.