38401-71-7

Basic information

• Product Name: 5-(4-CHLOROPHENYL)THIOPHENE-2-CARBALDEHYDE
• Synonyms: AKOS BAR-0521;5-(4-CHLOROPHENYL)-2-THIOPHENECARBALDEHYDE;5-(4-CHLOROPHENYL)THIOPHENE-2-CARBALDEHYDE;RARECHEM AK MA K020;5-(4-Chlorophenyl)thiophene-2-carboxaldehyde;5-(4-Chlorophenyl)-2-thiophenecarboxaldehyde;4-(2-Formylthiophene)chlorobenzene
• CAS NO: 38401-71-7
• Molecular Formula: C₁₁H₇ClOS
• Molecular Weight: 222.69
• Mol File: 38401-71-7.mol
• Article Data: 11

Chemical Properties

• Melting Point: 85-86°C
• Boiling Point: 367.4 °C at 760 mmHg
• Flash Point: 176 °C
• Appearance: /
• Density: 1.327 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-(4-CHLOROPHENYL)THIOPHENE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-CHLOROPHENYL)THIOPHENE-2-CARBALDEHYDE(38401-71-7)
• EPA Substance Registry System: 5-(4-CHLOROPHENYL)THIOPHENE-2-CARBALDEHYDE(38401-71-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 38401-71-7(Hazardous Substances Data)

Usage

General Description

5-(4-chlorophenyl)thiophene-2-carbaldehyde is a chemical compound with a molecular formula C12H7ClOS. It is a thiophene derivative with a substituted aldehyde group at the 2-position and a 4-chlorophenyl group at the 5-position. 5-(4-chlorophenyl)thiophene-2-carbaldehyde is commonly used as a building block in organic synthesis and pharmaceutical research. Its unique structure and functional groups make it a valuable starting material for the synthesis of diverse organic compounds, including biologically active molecules and pharmaceutical drugs. Its potential applications include the development of new drugs for various therapeutic purposes, as well as the production of advanced materials and fine chemicals. Furthermore, 5-(4-chlorophenyl)thiophene-2-carbaldehyde is of interest to researchers and chemists due to its versatile reactivity and potential for creating novel scaffolds and molecular structures.

Upstream product

• 1679-18-1 4-Chlorophenylboronic acid 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 98-03-3 thiophene-2-carbaldehyde 
• 106-47-8 4-chloro-aniline 
• 108-90-7 chlorobenzene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 40133-23-1 2-(4-chlorophenyl)thiophene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 950094-47-0 3-[5-(4-chloro-phenyl)-thiophen-2-yl]-acrylic acid 
• 95650-85-4 2-(4-chlorophenyl)-5-methylthiophene 
• 40133-23-1 2-(4-chlorophenyl)thiophene 
• 1313397-29-3 5-((5-(4-chlorophenyl)thiophen-2-yl)methylene)-2-thioxoimidazolidin-4-one 
• 1262511-89-6 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-(tetrahydro-pyran-4-ylmethyl)cyclopentane-1,3-dione 
• 1262512-76-4 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione 
• 1262512-74-2 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-5-[hydroxy-(tetrahydro-pyran-4-yl)methyl]-3-methoxy-cyclopent-2-enone 
• 1262512-72-0 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-3-methoxy-cyclopent-2-enone 
• 1262512-70-8 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]cyclopentane-1,3-dione 
• 1262512-68-4 3-[5-(4-chloro-phenyl)thiophen-2-ylmethoxy]cyclopent-2-enone 
• 1262511-91-0 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-4-(tetrahydro-furan-3-ylmethyl)cyclopentane-1,3-dione 
• 1262512-78-6 2-[5-(4-chloro-phenyl)-2-methyl-thiophen-3-yl]-3-methoxy-5-(tetrahydro-furan-3-ylmethyl)cyclopent-2-enone 
• 1195960-94-1 2-(4-((5-(4-chlorophenyl)thiophen-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 

Relevant articles and documents

Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane

As the continuous rise in the incidence of antibiotic resistance, it is urgent to develop novel chemical scaffolds with antibacterial activities to control the spread of resistance to conventional antibiotics. In this study, a series of phenylthiazole and

Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.

Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations

Protein arginine methyltransferase 5 (PRMT5) is an important protein arginine methyltransferase that catalyzes the symmetric dimethylation of arginine resides on histones or non-histone substrate proteins. It has been thought as a promising target for many diseases, particularly cancer. Despite the potential applications of PRMT5 inhibitors in cancer treatment, very few of PRMT5i have been publicly reported. In this investigation, virtual screening and structure–activity relationship studies were carried out to discover novel PRMT5i, which finally led to the identification of a number of new PRMT5i. The most active compound, P5i-6, exhibited a considerable inhibitory potency against PRMT5 with an IC50 value of 0.57?μm, and a high selectivity for PRMT5 against other tested PRMTs. It displayed a very good antiviability activity against two colorectal cancer cell lines, HT-29 and DLD-1, and one hepatic cancer cell line, HepG2, in a sensitivity assay against 36 different cancer cell lines. Western blot assays indicated that P5i-6 selectively inhibited the symmetric dimethylations of H4R3 and H3R8 in DLD-1 cells. Overall, P5i-6 could be used as a chemical probe to investigate new functions of PRMT5 in biology and also served as a good lead compound for the development of new PRMT5-targeting therapeutic agents.