38453-85-9

Basic information

• Product Name: 2-[2-(hydroxymethyl)phenyl]-1-phenylethanol
• CAS NO: 38453-85-9
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.2863
• Mol File: 38453-85-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 379.6°C at 760 mmHg
• Flash Point: 180.3°C
• Density: 1.17g/cm³
• Vapor Pressure: 1.94E-06mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 2-[2-(hydroxymethyl)phenyl]-1-phenylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(hydroxymethyl)phenyl]-1-phenylethanol(38453-85-9)
• EPA Substance Registry System: 2-[2-(hydroxymethyl)phenyl]-1-phenylethanol(38453-85-9)

Safety Data

• Hazardous Substances Data: 38453-85-9(Hazardous Substances Data)

Usage

Also known as

Hydroxymethylphenylethanol

Type of Compound

Phenylethanol derivative

Functional Groups

Hydroxyl and Benzyl

Usage

Commonly used in the production of perfumes and fragrances

Reason

Due to its pleasant smell and odor-masking properties

Potential Applications

Pharmaceutical industry

Role

Building block for the synthesis of various pharmaceutical compounds

Significance

Versatile building block for the synthesis of a wide range of organic compounds
Contributes to its importance in various industrial and research applications

Upstream product

• 4809-08-9 3-phenyl-isocoumarin 
• 100-52-7 benzaldehyde 
• 135-02-4 ortho-anisaldehyde 
• 98-86-2 acetophenone 
• 104-53-0 3-phenyl-propionaldehyde 
• 496-14-0 1,3-dihydroisobenzofuran 
• 89-95-2 2-methyl-benzyl alcohol 
• 2674-44-4 3-phenyl-isochroman-1-one 
• 2594-56-1 α'-hydroxy-bibenzyl-2-carboxylic acid 

Downstream Products

• 2674-44-4 3-phenyl-isochroman-1-one 
• 29539-18-2 (+/-)-3-phenylisochroman 
• 4505-48-0 2-phenylindene 

Relevant articles and documents

1H, 13C, 2D NMR and GCMS characterization of diol derivatives

Sodium borohydride (SBH) reduction of isocoumarins has been effected in presence of methanol to their respective diols. Diols have been isolated, purified and characterized by GCMS, proton, carbon and two-dimensional NMR spectroscopy analysis. Complete NMR assignments of diols are made using H-H COSY, as well as HSQC, HMQC and HMBC heteronuclear correlation techniques.

Polyphenylene as an electron transfer catalyst in lithiation processes

The lithiation of different functionalised chlorinated materials (1a-c), dichlorinated compounds (1d-f) and benzofused cyclic ethers (1g,h) with lithium powder in the presence of catalytic amounts of either linear (LPP) or crosslinked (CPP) polyphenylene, in THF at temperatures ranging between -78 and 20°C, leads to the expected organolithium intermediates (Ia-h), which by reaction with electrophiles [ButCHO, PhCHO, Et2CO, (CH2)5CO, PhCOMe, Me3SiCl] gives, after hydrolysis with water, the expected products 2aa-hf.

Electron-transfer-induced reductive cleavage of phthalans: Reactivity and synthetic applications

The behavior of phthalan (1a) was investigated under conditions of electron transfer from alkali metals in aprotic solvents. Reaction with lithium in the presence of a catalytic amount of naphthalene in THF led to the reductive cleavage of an arylmethyl carbon-oxygen bond, with formation of a stable dilithium compound. Trapping of this intermediate with several electrophiles (alkyl halides, carbonyl derivatives, CO2) was successful. The extension of this procedure to several substituted phthalans (1b-i) was investigated, and the regiochemistry as well as the synthetic usefulness of these reactions are discussed.