3846-49-9

Basic information

• Product Name: 1,3-diethyl-1,3-bis(4-nitrophenyl)urea
• Synonyms: 1,3-diethyl-1,3-bis(4-nitrophenyl)urea;N,N'-Diethyl-N,N'-bis(4-nitrophenyl)urea;Ai3-27440;Einecs 223-344-5;Urea, N,N'-diethyl-N,N'-bis(4-nitrophenyl)-
• CAS NO: 3846-49-9
• Molecular Formula: C₁₇H₁₈N₄O₅
• Molecular Weight: 358.34862
• EINECS: 223-344-5
• Mol File: 3846-49-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 530.2°Cat760mmHg
• Flash Point: 274.5°C
• Appearance: /
• Density: 1.359g/cm³
• Vapor Pressure: 2.51E-11mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: 1,3-diethyl-1,3-bis(4-nitrophenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-diethyl-1,3-bis(4-nitrophenyl)urea(3846-49-9)
• EPA Substance Registry System: 1,3-diethyl-1,3-bis(4-nitrophenyl)urea(3846-49-9)

Safety Data

• Hazardous Substances Data: 3846-49-9(Hazardous Substances Data)

Usage

Chemical compound

Yes

Usage

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Physical state

White crystalline solid

Solubility

Insoluble in water, soluble in organic solvents

Application

Reagent in organic chemistry for the production of various compounds

Additional properties

Antibacterial and antifungal

Potential use

Insecticide

Safety concerns

Potential explosive when exposed to heat or friction

Handling

Careful handling required due to explosive potential

InChI:InChI=1/C17H18N4O5/c1-3-18(13-5-9-15(10-6-13)20(23)24)17(22)19(4-2)14-7-11-16(12-8-14)21(25)26/h5-12H,3-4H2,1-2H3

Upstream product

• 85-98-3 ethyl centralite 
• 100-28-7 4-Nitrophenyl isocyanate 
• 75-44-5 phosgene 
• 3665-80-3 N-Ethyl-4-nitroanilin 
• 2733-41-7 4-nitrobenzoyl azide 
• 7697-37-2 nitric acid 
• 587-90-6 bis-N,N'-(4-nitrophenyl)urea 
• 75-03-6 ethyl iodide 

Downstream Products

• 4596-98-9 1,3-bis(2,4-dinitrophenyl)-1,3-diethylurea 
• 78277-86-8 N,N'-diethyl-N-(2,4-dinitro-phenyl)-N'-(4-nitro-phenyl)-urea 
• 3665-80-3 N-Ethyl-4-nitroanilin 

Relevant articles and documents

Synthesis, characterization and antibacterial activity of novel 1,3-diethyl-1,3-bis(4-nitrophenyl)urea and its metal(II) complexes

A bioactive ligand and its dinuclear metal(II) complexes were synthesized and characterized by Fourier-transform infrared spectroscopy (FT-IR), ultraviolet-visible (UV-Visible), nuclear magnetic resonance (1H-NMR), mass spectroscopy and molar conductance measurements. The ligand has been crystalized in the monoclinic system with a P21/c space group. The biological activities of metal complexes were evaluated using disc diffusion and broth dilution methods. In vitro antibacterial activities of the ligand and their metal complexes were examined against two Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and two Gram-negative bacteria (Escherichia coli and Serratia marcescens) and compared to the standard drugs. It was found that metal complexes displayed much higher antibacterial activities and better inhibitory effects than that of the ligand and standard drugs. Among these complexes, the compound having Zn-metal showed greater antibacterial activity against all four tested bacteria and was more effective against Serratia marcescens with the zone inhibition diameter of 26 mm and MIC value of 31.25 μg/mL.