38474-02-1

Basic information

• Product Name: Benzene, 1-(ethylthio)-3-methoxy-
• CAS NO: 38474-02-1
• Molecular Formula: C9H12OS
• Molecular Weight: 168.26
• Mol File: 38474-02-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(ethylthio)-3-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(ethylthio)-3-methoxy-(38474-02-1)
• EPA Substance Registry System: Benzene, 1-(ethylthio)-3-methoxy-(38474-02-1)

Safety Data

• Hazardous Substances Data: 38474-02-1(Hazardous Substances Data)

Upstream product

• 456-49-5 1-fluoro-3-methoxybenzene 
• 75-08-1 ethanethiol 
• 15570-12-4 3-methoxybenzenethiol 
• 75-03-6 ethyl iodide 
• 118736-36-0 1,1-bis(benzenesulphonyl)-5-(3-methoxybenzenethio)pentane 
• 118736-31-5 1,1-bis(benzenesulphonyl)-4-(3-methoxybenzenethio)butane 
• 118736-27-9 1,1-bis(benzenesulphonyl)-3-(3-methoxybenzenethio)propane 
• 118736-26-8 1-iodo-2-(3-methoxybenzenethio)ethane 
• 175154-41-3 1-chloro-2-(3-methoxybenzenethio)ethane 
• 2388-74-1 1-methoxy-3-methylsulfanyl-benzene 
• 74-88-4 methyl iodide 

Downstream Products

• 1074-44-8 3-(ethylthio)phenol 

Relevant articles and documents

NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS

This invention relates to nicotinamide derivatives of formula (I) and to pharmaceutical compositions containing, and the uses of such derivatives as PDE4 inhibitors wherein R7 is attached to the 3-or 4-position of the phenyl ring and is S(O)pR8, R8 is (C1-C4)alkyl optionally substituted by (C3-C6)cycloalkyl; m is 0 or 1; L is a (C3-C8)carbocyclic non-aromatic ring; and the remaining variables are as defined in the claims.

METALATION REACTIONS. XIV. REGIOSPECIFIC PREPARATION OF POLYSUBSTITUTED BENZENES VIA MONO- OR DI-LITHIATION REACTIONS OF AROMATIC THIOETHERS

The preparation of polyfunctionalized aromatic thioethers either by one-step dilithiation or by two successive one-flask monometalation reactions is described.By acting on 1 two equal or different electrophiles one on the thiomethyl group and one in the ortho-position with respect to it are introduced; by acting on 11 and on 35 the substitution involves the thiomethyl carbon atom and that in the ortho-position with respect to the alkoxy group.In the case of the homologeous isopropylthio (23) the substitution involves the two aryl carbon atoms in the ortho-position to both functions.In the case of the p-disubstituted isomers (49, 59) analogous behaviour to ortho isomers in one-step metalation reaction is observed, while the two hydrogen atoms in the ortho-positions to the methoxy group are substituted when two successive monometalations are employed.The metalation of 40 results low selective.The behaviour of 79 and 93 is analogous to 1, while 72, 88 and 96 undergo only one-step monometalation reactions.

SELECTIVE CLEAVAGE OF THE CARBON-SULPHUR AND CARBON-OXYGEN BONDS IN METHOXYTHIOANISOLES

Selective cleavage of thioether or ether functions in methoxythioanisoles in hexamehtylphosphoramide (HMPA) with sodium gives methoxythiophenols by cleavage of the carbon-sulphur bond.Reactions with sodium isopropanethiolate give instead the thiomethoxyphenols by dealkylation of the methoxy function.When the methoxythioanisoles were treated first with sodium isopropanethiolate and then with sodium complete dealkylation was achieved with formation of mercaptophenols.The present methods have considerable advantages over existing procedures for the synthesis of methoxythiophenols, thiomethoxyphenols and mercaptophenols.The mechanistic implications of the reactions investigated are also discussed.