38489-78-0

Basic information

• Product Name: 3-(2-HYDROXY-5-METHOXY-PHENYL)-ACRYLIC ACID
• Synonyms: (E)-3-(2-hydroxy-5-methoxyphenyl)acrylic acid
• CAS NO: 38489-78-0
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.18
• Mol File: 38489-78-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 402.7°C at 760 mmHg
• Flash Point: 164.2°C
• Appearance: /
• Density: 1.316g/cm³
• Vapor Pressure: 3.3E-07mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 3-(2-HYDROXY-5-METHOXY-PHENYL)-ACRYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-HYDROXY-5-METHOXY-PHENYL)-ACRYLIC ACID(38489-78-0)
• EPA Substance Registry System: 3-(2-HYDROXY-5-METHOXY-PHENYL)-ACRYLIC ACID(38489-78-0)

Safety Data

• Hazardous Substances Data: 38489-78-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10O4/c1-14-8-3-4-9(11)7(6-8)2-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-2+

Upstream product

• 85364-68-7 3-methyl-4-nitro-5-<2-(2-hydroxy-5-methoxyphenyl)ethenyl>isoxazole 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 141-82-2 malonic acid 
• 1530-45-6 (carbethoxymethyl)triphenylphosphonium bromide 
• 17372-53-1 6-methoxycoumarin 

Downstream Products

• 1415264-79-7 (E)-3-(5-methoxy-2-((3,5,6-trimethylpyrazine-2-carbonyl)oxy)phenyl)acrylic acid 
• 1415264-91-3 (E)-2-(3-ethoxy-3-oxoprop-1-en-1-yl)-4-methoxyphenyl 3,5,6-trimethylpyrazine-2-carboxylate 

Relevant articles and documents

Design, synthesis and biological evaluation of novel trimethylpyrazine-2- carbonyloxy-cinnamic acids as potent cardiovascular agents

A series of novel trimethylpyrazine-2-carbonyloxy-cinnamic acids and esters were designed, synthesized and evaluated for their inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation in vitro and also assayed for their protective effect against hydrogen peroxide (H 2O2)-induced oxidative damage on Ea.hy926 cells. The results showed that many compounds exhibited high activity in one or both of the assays, of which, compound F′10 displayed the highest protective effect on the proliferation of the damaged Ea.hy926 cells (EC50 = 1.7 μM), presenting almost 40 times higher potency than that of lipoic acid, and compound F3 was the most active anti-platelet aggregation agent with IC 50 = 9.6 μM, comparable to that of clopidogrel. The structure-activity relationships of these compounds were also discussed.

THE PREPARATION OF COUMARIC ACIDS VIA STYRYLISOXAZOLES

The preparation of coumaric acids (2a-f) by hydrolysis of the requisite 3-methyl-4-nitro-5-styrylisoxazoles (1a-f) is reported.