38557-71-0 Usage
Description
2-Chloro-6-methylpyrazine is an organic compound with the molecular formula C5H5ClN2. It is a solid substance that belongs to the class of pyrazines, which are heterocyclic compounds with two nitrogen atoms in the ring. This particular compound has a chlorine atom at the 2nd position and a methyl group at the 6th position, which gives it unique chemical properties and potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
2-Chloro-6-methylpyrazine is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the synthesis of palm site inhibitors of HCV NS5B polymerase, which are essential in the treatment of Hepatitis C Virus (HCV) infections. These inhibitors help to block the replication of the virus, thereby reducing its impact on the infected individual.
Additionally, 2-Chloro-6-methylpyrazine is also used as a synthetic intermediate for the development of potent dipeptidyl peptidase IV (DPP-IV) inhibitors. DPP-IV inhibitors play a crucial role in the management of type 2 diabetes by regulating the levels of glucose in the body. They work by increasing the levels of insulin and decreasing the levels of glucagon, thus helping to maintain a balanced blood sugar level.
Check Digit Verification of cas no
The CAS Registry Mumber 38557-71-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,5,5 and 7 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 38557-71:
(7*3)+(6*8)+(5*5)+(4*5)+(3*7)+(2*7)+(1*1)=150
150 % 10 = 0
So 38557-71-0 is a valid CAS Registry Number.
38557-71-0Relevant articles and documents
Production method of 2-methyl-3(5 or 6)-methylthio pyrazine
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Paragraph 0027-0028; 0031-0032, (2020/04/17)
The invention discloses a production method of 2-methyl-3(5 or 6)-methylthio pyrazine. The method comprises the following steps: adding solvents dichloroethane and triethylamine into a reaction kettle, sealing the reaction kettle, introducing chlorine to control the pressure in the kettle at 0.02-0.03 MPa, pumping a methylpyrazine solution into the reaction kettle by using a metering pump, controlling the temperature at 45-60 DEG C, reacting, and transferring reaction liquid(containing the chlorine)in the kettle into a dichloroethane turnover tank through filter pressing for recycling after the reaction is finished; dissolving the residual 2-methyl-3(5 or 6)-chloropyrazine hydrochloride solid in the reaction kettle with water, adjusting the neutrality, and layering to obtain a 2-methyl-3(5or 6)-chloropyrazine crude product; and dropwise adding thechloropyrazine crude product is into sodium methyl mercaptide, performing reflux reaction , and after reaction liquid is extracted, adding an aid into an organic phase to generate a hydrochloride for separating the non-pyrazine product from the product to greatly improve the aroma quality of the obtained product. The product grade is improved, and the whole production process is safe and environmentally friendly.