38585-61-4

Basic information

• Product Name: 4-(Chloromethyl)-1H-imidazole hydrochloride
• Synonyms: 5-(CHLOROMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE;4-chloromethyl-imidazolhydrochloride;4-Chloromethy-1(3)H-imidazole Hydrochlorid;4-Chloromethy-1H-imidazole Hydrochloride;1H-Imidazole, 4-(chloromethyl)-, monohydrochloride (9CI);4-(Chloromethyl)-1H-imidazole hydrochloride;4-Chloromethyl-1(3)H-imidazole Hydrochloride;1H-IMidazole, 4-(chloroMethyl)-, Monohydrochloride
• CAS NO: 38585-61-4
• Molecular Formula: C₄H₅ClN₂*ClH
• Molecular Weight: 153.01
• Product Categories: Heterocycles
• Mol File: 38585-61-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 1400C
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Ethanol, Methanol, Tetrahydrofuran, Toluene
• CAS DataBase Reference: 4-(Chloromethyl)-1H-imidazole hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Chloromethyl)-1H-imidazole hydrochloride(38585-61-4)
• EPA Substance Registry System: 4-(Chloromethyl)-1H-imidazole hydrochloride(38585-61-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 38585-61-4(Hazardous Substances Data)

Usage

Description

4-(Chloromethyl)-1H-imidazole hydrochloride, with the CAS number 38585-61-4, is a beige solid compound that is widely utilized in the field of organic synthesis. It is known for its unique chemical properties that make it a valuable component in various chemical reactions and processes.

Uses

Used in Organic Synthesis:
4-(Chloromethyl)-1H-imidazole hydrochloride is used as a synthetic building block for the creation of various organic compounds. Its application in organic synthesis is due to its reactive chloromethyl group, which can easily participate in a range of chemical reactions, such as nucleophilic substitution, to form a variety of products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-(Chloromethyl)-1H-imidazole hydrochloride is used as a key intermediate in the synthesis of various drugs and drug candidates. Its unique chemical structure allows for the development of new molecules with potential therapeutic applications, contributing to the advancement of medicinal chemistry.
Used in Chemical Research:
4-(Chloromethyl)-1H-imidazole hydrochloride is also employed in chemical research as a versatile reagent for exploring new reaction pathways and understanding the fundamental principles of organic chemistry. Its use in research helps to expand the knowledge base in the field and can lead to the discovery of novel chemical processes and applications.
Used in Material Science:
In the field of material science, 4-(Chloromethyl)-1H-imidazole hydrochloride is utilized in the development of new materials with specific properties. Its incorporation into various chemical structures can result in materials with unique characteristics, such as improved stability, reactivity, or selectivity, which can be applied in a range of industries.

Upstream product

• 32673-41-9 4-hydroxymethyl-1H-imidazole hydrochloride 

Downstream Products

• 104926-40-1 1H-imidazol-4-yl-N,N-dimethylmethanamine 
• 147314-99-6 benzoic acid 1-(ethoxycarbonyl)-1-(3H-imidazol-4-yl-methyl)-4-methyl-2-oxopentyl ester 
• 1258423-02-7 N-((1H-imidazol-5-yl)methyl)-N-(2-(5-chloro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-5-methoxyphenyl)methanesulfonamide 
• 145874-66-4 1-(2,4-dinitrophenyl)-3-(chloromethyl)imidazole 
• 79853-10-4 3-(imidazol-4-yl)-2-phenyl-2-(2-pyridyl)-propanenitrile 
• 78448-25-6 3-(imidazol-4-yl)-2,2-diphenylpropanenitrile 

Relevant articles and documents

Aminooxy analog of histamine is an efficient inhibitor of mammalian l-histidine decarboxylase: Combined in silico and experimental evidence

Histamine plays highlighted roles in the development of many common, emergent and rare diseases. In mammals, histamine is formed by decarboxylation of l-histidine, which is catalyzed by pyridoxal-5′-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22). The limited availability and stability of the protein have delayed the characterization of its structure-function relationships. Our previous knowledge on mammalian HDC, derived from both in silico and experimental approaches, indicates that an effective competitive inhibitor should be capable to form an "external aldimine-like structure" and have an imidazole group, or its proper mimetic, which provides additional affinity of PLP-inhibitor adduct to the HDC active center. This is confirmed using HEK-293 cells transfected to express human HDC and the aminooxy analog of histidine, 4(5)-aminooxymethylimidazole (O-IMHA, IC50 ≈ 2 × 10-7M) capable to form a PLP-inhibitor complex (oxime) in the enzyme active center. Taking advantage of the availability of the human HDC X-ray structure, we have also determined the potential interactions that could stabilize this oxime in the active site of mammalian HDC.

THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein w, R1, q, p, R2, t, Ar1, L1, R3 and R4 are as defined, or a pharmaceutically acceptable salt, solvate, or enantiomer thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.

Cholecystokinin antagonists

Benzodiazepine analogs of the formula: STR1 are disclosed which are antagonists of gastrin and cholecystokinin (CCK).