38635-54-0

Basic information

• Product Name: [(2,4-dichlorobenzylidene)(2-nitro-4-trifluorobenzyl)]acetic acid
• Synonyms: [(2,4-dichlorobenzylidene)(2-nitro-4-trifluorobenzyl)]acetic acid;α-(2,4-Dichlorobenzylidene)-2-nitro-4-(trifluoromethyl)benzeneacetic acid;Benzeneacetic acid, a-[(2,4-dichlorophenyl)Methylene]-2-nitro-4-(trifluoroMethyl)-
• CAS NO: 38635-54-0
• Molecular Formula: C₁₆H₈Cl₂F₃NO₄
• Molecular Weight: 408.1561096
• EINECS: 254-047-9
• Mol File: 38635-54-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 457.8°Cat760mmHg
• Flash Point: 230.6°C
• Appearance: /
• Density: 1.584g/cm³
• Vapor Pressure: 3.58E-09mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: [(2,4-dichlorobenzylidene)(2-nitro-4-trifluorobenzyl)]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(2,4-dichlorobenzylidene)(2-nitro-4-trifluorobenzyl)]acetic acid(38635-54-0)
• EPA Substance Registry System: [(2,4-dichlorobenzylidene)(2-nitro-4-trifluorobenzyl)]acetic acid(38635-54-0)

Safety Data

• Hazardous Substances Data: 38635-54-0(Hazardous Substances Data)

Usage

Description

[(2,4-dichlorobenzylidene)(2-nitro-4-trifluorobenzyl)]acetic acid is a complex organic chemical compound with a unique structure that features a dichlorobenzylidene group and a nitro-trifluorobenzyl group attached to an acetic acid backbone. [(2,4-dichlorobenzylidene)(2-nitro-4-trifluorobenzyl)]acetic acid has garnered attention in the pharmaceutical field due to its potential applications in medicine, particularly as an anti-inflammatory agent.

Uses

Used in Pharmaceutical Industry:
[(2,4-dichlorobenzylidene)(2-nitro-4-trifluorobenzyl)]acetic acid is used as an anti-inflammatory agent for its ability to inhibit the production of prostaglandins, which play a key role in the inflammatory response. This makes it a candidate for the development of treatments targeting conditions characterized by inflammation.
Used in Dermatological Applications:
In the dermatology field, [(2,4-dichlorobenzylidene)(2-nitro-4-trifluorobenzyl)]acetic acid is used as a potential treatment for various skin conditions such as psoriasis and eczema. Its pharmacological properties suggest that it could help manage the symptoms of these conditions by reducing inflammation and other related skin reactions.
As a subject of ongoing research, [(2,4-dichlorobenzylidene)(2-nitro-4-trifluorobenzyl)]acetic acid holds promise for future applications in medicine, pending further investigation into its safety, efficacy, and optimal delivery methods.

InChI:InChI=1/C16H8Cl2F3NO4/c17-10-3-1-8(13(18)7-10)5-12(15(23)24)11-4-2-9(16(19,20)21)6-14(11)22(25)26/h1-7H,(H,23,24)

Upstream product

• 1735-91-7 2-(2-nitro-4-(trifluoromethyl)phenyl)acetic acid 
• 874-42-0 2,4-dichlorobenzaldeyhde 

Downstream Products

• 38492-84-1 1,3-dichloro-6-(trifluoromethyl)phenanthren-9-carboxaldehyde 
• 38492-81-8 1,3-dichloro-6-(trifluoromethyl)phenanthren-9-methanol 
• 38635-85-7 1,3-dichloro-6-(trifluoromethyl)phenanthren-9-carboxylic acid 

Relevant articles and documents

3-Hydroxy-N′-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally

Structural optimization of 3-hydroxy-N′-arylidenepropanehydrazonamides provided new analogs with nanomolar to subnanomolar antiplasmodial activity against asexual blood stages of Plasmodium falciparum, excellent parasite selectivity, and nanomolar activity against the earliest forms of gametocyte development. Particularly, derivatives with a 1,3-dihalo-6-trifluoromethylphenanthrene moiety showed outstanding in vivo properties and demonstrated in part curative activity in the Plasmodium berghei mouse model when administered perorally.