38697-79-9Relevant articles and documents
Synthesis and description of intermolecular interactions in new sulfonamide derivatives of tranexamic acid
Ashfaq, Muhammad,Arshad, Muhammad Nadeem,Danish, Muhammad,Asiri, Abdullah M.,Khatoon, Sadia,Mustafa, Ghulam,Zolotarev, Pavel N.,Butt, Rabia Ayub,?ahin, Onur
, p. 271 - 280 (2016)
Tranexamic acid (4-aminomethyl-cyclohexanecarboxylic acid) was reacted with sulfonyl chlorides to produce structurally related four sulfonamide derivatives using simple and environmental friendly method to check out their three-dimensional behavior and va
Synthesis of new thiophene and benzo[b]thiophene hydrazide derivatives as human NPY Y5 antagonists
Galiano, Silvia,Erviti, Oihana,Perez, Silvia,Moreno, Antonio,Juanenea, Laura,Aldana, Ignacio,Monge, Antonio
, p. 597 - 599 (2007/10/03)
Neuropeptide Y is one of the most potent appetite stimulating hormones known. Novel thiophene and benzo[b]thiophene hydrazide derivatives were synthetized and evaluated biologically as NPY Y1 and Y5 receptor subtype antagonists. They were found to have nanomolar binding affinities for human NPY Y5 receptor, obtaining the lead compound, trans-N-4-[N′-(thiophene-2-carbonyl)hydrazinocarbonyl]cyclohexylmethyl-4- bromobenzenesulfonamide, which binds with a 7.70 nM IC50 to the hY5 receptor.
