38711-20-5

Basic information

• Product Name: DIMETHYLAMINOACETALDEHYDE DIMETHYLACETAL
• Synonyms: N-(2,2-DIMETHOXYETHYL)DIMETHYLAMINE;2,2-dimethoxy-n,n-dimethyl-ethanamin;2,2-Dimethoxy-N,N-dimethylethanamine;Ethanamine, 2,2-dimethoxy-N,N-dimethyl-;DIMETHYLAMINOACETALDEHYDE DIMETHYLACETAL;2,2-DIMETHOXY-N,N-DIMETHYLETHYLAMINE;Dinethylaminoacetaldehydediethylacetal;Dinethylamino-acetaldehyde-diethylacetal
• CAS NO: 38711-20-5
• Molecular Formula: C₆H₁₅NO₂
• Molecular Weight: 133.19
• EINECS: 254-097-1
• Product Categories: Aromatic Aldehydes & Derivatives (substituted)
• Mol File: 38711-20-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 64 °C
• Flash Point: 32°C
• Appearance: Clear colorless to slightly yellow/Liquid
• Density: 0.9
• Vapor Pressure: 1.86mmHg at 25°C
• Refractive Index: 1.4060-1.4100
• Storage Temp.: Flammables area
• PKA: 9.35±0.28(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: DIMETHYLAMINOACETALDEHYDE DIMETHYLACETAL(CAS DataBase Reference)
• NIST Chemistry Reference: DIMETHYLAMINOACETALDEHYDE DIMETHYLACETAL(38711-20-5)
• EPA Substance Registry System: DIMETHYLAMINOACETALDEHYDE DIMETHYLACETAL(38711-20-5)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38-34
• Safety Statements: 26-36/37/39-45-16
• RIDADR: 2733
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 38711-20-5(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

InChI:InChI=1/C6H15NO2/c1-6(2,7)5(8-3)9-4/h5H,7H2,1-4H3

Upstream product

• 7252-83-7 1-bromo-2,2-dimethoxyethane 
• 124-40-3 dimethyl amine 
• 97-97-2 chloroacetaldehyde dimethyl acetal 

Downstream Products

• 2135696-72-7 (E)-N-(4-((3-bromo-4-chlorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)-4-(dimethylamino)but-2-enamide 
• 83490-20-4 N′-carbamothioyl-N,N-dimethylformimidamide 
• 887588-48-9 tert-butyl (3R)-3-{[2-(dimethylamino)ethyl]amino}piperidine-1-carboxylate 
• 125969-54-2 2-(dimethylamino)-acetaldehyde hydrochloride 
• 52334-92-6 2-(N,N-dimethylamino)ethoxide 

Relevant articles and documents

Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing 2,3-dihydro-indole or 1,2,3,4-tetrahydroquinoline as potential EGFR inhibitors

Eight series of quinazoline derivatives bearing 2,3-dihydro-indole or 1,2,3,4-tetrahydroquinoline were designed, synthesized and evaluated for the IC50 values against three cancer cell lines (A549, MCF-7 and PC-3). Most of the forty nine target compounds showed excellent antiproliferative activity against one or several cancer cell lines. The compound 13a showed the best activity against A549, MCF-7 and PC-3 cancer cell lines, with the IC50 values of 1.09 ± 0.04 μM, 1.34 ± 0.13 μM and 1.23 ± 0.09 μM, respectively. Eight selected compounds were further selected to evaluated for the inhibitory activity against EGFR kinase. Three of them showed equal activity against EGFR kinase to positive control afatinib. AnnexinV-FITC, propidium iodide (PI) double staining and acridine orange single staining results indicated that the compound 13a could induce apoptosis of human lung cancer A549 cells.