38749-79-0

Basic information

• Product Name: 3-Bromo-2-methylpyridine
• Synonyms: 3-BROMO-2-METHYLPYRIDINE;3-BROMO-2-PICOLINE;2-METHYL-3-BROMOPYRIDINE;Pyridine, 3-bromo-2-methyl-;3-bromo-2-methylpridine;3-Bromo-5-fluoro-2-methoxypyrdine 2-METHYL-3-BROMOPYRIDINE 98+%;3-BROMO-2-METHYLPYRIDINE (3-BROMO-2-PICOLINE)
• CAS NO: 38749-79-0
• Molecular Formula: C₆H₆BrN
• Molecular Weight: 172.02
• EINECS: -0
• Product Categories: compounds of pyridine;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridines;Pyridines derivates;Pyridine Derivertives;Organohalides;Bromopyridines;Halopyridines;Boronic Acid;Pyridine Series
• Mol File: 38749-79-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 76°C/17mm
• Flash Point: 174°F
• Appearance: Clear, colorless to brown/Liquid
• Density: 1.495
• Vapor Pressure: 1.27mmHg at 25°C
• Refractive Index: 1.5604
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.59±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-2-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2-methylpyridine(38749-79-0)
• EPA Substance Registry System: 3-Bromo-2-methylpyridine(38749-79-0)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41-36/37/38-20/21/22
• Safety Statements: 26-36/39-36-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 38749-79-0(Hazardous Substances Data)

Usage

Description

3-Bromo-2-methylpyridine is an organic compound that belongs to the pyridine family. It is characterized by the presence of a bromine atom at the 3rd position and a methyl group at the 2nd position on the pyridine ring. 3-Bromo-2-methylpyridine is known for its unique chemical properties and reactivity, making it a valuable intermediate in the synthesis of various organic compounds.

Uses

Used in Organic Synthesis:
3-Bromo-2-methylpyridine is used as a key intermediate in the synthesis of various organic compounds, particularly in the production of pharmaceuticals, agrochemicals, and other specialty chemicals. Its reactivity allows for a wide range of chemical transformations, making it a versatile building block in organic chemistry.
Used in the Production of Pyridine Carboxaldehyde:
3-Bromo-2-methylpyridine is used as a starting material for the conversion to the corresponding pyridine carboxaldehyde. This conversion is achieved through a peroxide-initiated NBS gem-dibromination followed by hydrolysis. The resulting pyridine carboxaldehyde can be further utilized in the synthesis of various pharmaceuticals and agrochemicals, highlighting the importance of 3-Bromo-2-methylpyridine in the development of new and innovative products.

InChI:InChI=1/C6H6BrN/c1-5-6(7)3-2-4-8-5/h2-4H,1H3

Upstream product

• 109-06-8 α-picoline 
• 626-55-1 3-Bromopyridine 

Downstream Products

• 122957-52-2 3-(4-cyanophenyl)-2-methylpyridine 
• 122851-60-9 2-(3-bromopyridin-2-yl)acetonitrile 
• 99455-24-0 2-Methoxy-6-(2-methyl-pyridin-3-yl)-quinoline 
• 188824-82-0 2-Methyl-3-((S)-toluene-4-sulfinyl)-pyridine 
• 197376-41-3 ethyl 2-(3-bromopyridin-2-yl)acetate 
• 3256-89-1 2-methyl-3-phenylpyridine 
• 52583-59-2 2-methyl-3-(3-nitrophenyl)pyridine 
• 1012084-56-8 2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine 
• 1173897-86-3 5-bromo-6-methylpyridine-2-carbonitrile 

Relevant articles and documents

Acid secretion inhibitor

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.

Novel 3beta-amino azabicyclooctane heteroaromatic amid derivatives preparation method and therapeutic uses thereof

The invention concerns compounds of general formula 1, wherein: A, B, D and E represent one or two nitrogen atoms, the others being carbon atoms; X represents a S or, a O, thereby forming a bicyclic fused heteroaromatic, such as thieno[2,3-b]pyridine, furo[2,3-b]pyridine, thieno[3,2-b]pyridine, furo[3,2-b]pyridine, thieno[2,3-b]pyrazine, furo[2,3-b]pyrazine, thieno[2,3-c]pyridine, furo[2,3-c]pyridine, thieno[3,2-c]pyridine and furo[3,2-c]pyridine; R1 represents a linear or branched C1-C6 alkoxy group, a linear or branched C1-C6 alkylthio group; R2 represents a linear, branched, cyclic C2-C8 group, a 2- or 3- thienylmethyl group, or a benzyl group optionally substituted by one or several halogens, F, Cl, Br, I, C1-C4 alkyl, C1-C4 alkoxy, CF3, CN, NO2, OH; and their pharmaceutically acceptable salts. Said compounds are anti-dopaminergic agents.

Structure-activity relationships in the 2-arylcarbapenem series: Synthesis of 1-methyl-2-arylcarbapenems

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