387827-33-0

Basic information

• Product Name: 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-(4-nitrophenyl)-, 1,1-dimethylethyl ester
• CAS NO: 387827-33-0
• Molecular Formula: C16H20N2O4
• Molecular Weight: 304.346
• Mol File: 387827-33-0.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-(4-nitrophenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-(4-nitrophenyl)-, 1,1-dimethylethyl ester(387827-33-0)
• EPA Substance Registry System: 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-(4-nitrophenyl)-, 1,1-dimethylethyl ester(387827-33-0)

Safety Data

• Hazardous Substances Data: 387827-33-0(Hazardous Substances Data)

Usage

Description

1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-(4-nitrophenyl)-, 1,1-dimethylethyl ester, commonly known as tadalafil, is a chemical compound with the molecular formula C17H20N2O4. It is a prescription medication that belongs to the class of drugs known as phosphodiesterase-5 (PDE5) inhibitors. Tadalafil works by increasing blood flow to the penis, allowing for a stronger and longer-lasting erection. It is used to treat erectile dysfunction and symptoms of benign prostatic hyperplasia. Tadalafil has a relatively long duration of action, with its effects lasting for up to 36 hours, making it a widely used treatment for erectile dysfunction. However, it can cause side effects such as headache, indigestion, and muscle aches in some individuals.

Uses

Used in Pharmaceutical Industry:
1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-(4-nitrophenyl)-, 1,1-dimethylethyl ester is used as a prescription medication for the treatment of erectile dysfunction and symptoms of benign prostatic hyperplasia. It is used to increase blood flow to the penis, allowing for a stronger and longer-lasting erection.
Used in Research and Development:
Tadalafil is also used in research and development for the study of PDE5 inhibitors and their potential applications in various medical conditions. This includes the investigation of its effects on blood flow and its potential use in treating other conditions related to blood flow and vascular health.
Used in Drug Delivery Systems:
Similar to gallotannin, tadalafil can be incorporated into drug delivery systems to enhance its efficacy and bioavailability. Various organic and metallic nanoparticles can be employed as carriers for tadalafil delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes.

Upstream product

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• 171364-83-3 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene 
• 24067-17-2 4-nitrophenylboronic acid 

Downstream Products

• 1383706-16-8 4-(4-nitrophenyl)-1,2,3,6-tetrahydropyridine hydrochloride 
• 1612155-93-7 tert-butyl 4-(4-acetamidophenyl)piperidine-1-carboxylate 
• 873454-43-4 4-(4-aminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 1393900-65-6 2-(3-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide 
• 1393900-64-5 2-(3-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide 
• 1393901-55-7 tert-butyl 4-(4-((4-(2-(3-(2-amino-2-oxoethyl)pyrazin-2-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393901-54-6 tert-butyl 4-(4-((4-(2-(3-(2-ethoxy-2-oxoethyl)pyrazin-2-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393901-53-5 tert-butyl 4-(4-((4-((3-(2-ethoxy-2-oxoethyl)pyrazin-2-yl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 
• 1393900-76-9 2-(2-(2-(2-((4-(1-ethylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyridin-3-yl)acetamide 
• 1393900-72-5 2-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isonicotinamide 
• 1393901-72-8 2-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)isonicotinamide 
• 1393901-71-7 tert-butyl 4-(4-((4-(2-(4-carbamoylpyridin-2-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate 

Relevant articles and documents

Pyrrolopyrimidine compound, pharmaceutical composition containing thereof, and preparation method and applications

The invention relates to a pyrrolopyrimidine compound represented by formula I, a pharmaceutical composition containing thereof, and a preparation method and applications in preventing or treating Weel protein kinase related diseases.

PHARMACEUTICAL COMPOUND

Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises the general formula (I) detailed within.

PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS

The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.