38786-79-7Relevant articles and documents
Discovery of dimeric inhibitors by extension into the entrance channel of HIV-1 reverse transcriptase
Ekkati, Anil R.,Bollini, Mariela,Domaoal, Robert A.,Spasov, Krasimir A.,Anderson, Karen S.,Jorgensen, William L.
scheme or table, p. 1565 - 1568 (2012/03/26)
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase is being pursued with computational guidance. Extension of azine-containing inhibitors into the entrance channel between Lys103 and Glu138 has led to the discovery of potent and structurally novel derivatives including dimeric inhibitors in an NNRTI-linker-NNRTI motif.
PURINE DERIVATIVES AS IMMUNOMODULATORS
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, (2008/12/08)
The present invention includes novel compounds useful in the treatment of various disorders in particular infectious diseases, cancer, and allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, and as vaccine adjuvants
Triisobutylaluminum-Assisted Reductive Rearrangement of Alkyl 1-Alkenyl Acetals: An Easy Synthesis of β-Alkoxy Alcohols
Menicagli, R.,Malanga, C.,Dell'Innocenti, M.,Lardicci, L.
, p. 5700 - 5704 (2007/10/02)
Alkyl 1-alkenyl acetals react with Al-i-Bu3 to give very good yields of β-alkoxy alcohols through a reductive rearrangement.The reaction is totally regioselective, but no stereocontrol occurs.