388-31-8

Basic information

• Product Name: Ethanone,2-bromo-1-(4-fluoro-1-naphthalenyl)-
• Synonyms: Ethanone,2-bromo-1-(4-fluoro-1-naphthalenyl)-;2-Bromo-1-(4-fluoronaphthalen-1-yl)ethan-1-one
• CAS NO: 388-31-8
• Molecular Formula: C12H8BrFO
• Molecular Weight: 267.1
• Mol File: 388-31-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 362.2°Cat760mmHg
• Flash Point: 172.9°C
• Appearance: /
• Density: 1.548g/cm³
• Vapor Pressure: 1.96E-05mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: Ethanone,2-bromo-1-(4-fluoro-1-naphthalenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone,2-bromo-1-(4-fluoro-1-naphthalenyl)-(388-31-8)
• EPA Substance Registry System: Ethanone,2-bromo-1-(4-fluoro-1-naphthalenyl)-(388-31-8)

Safety Data

• Hazardous Substances Data: 388-31-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H8BrFO/c13-7-12(15)10-5-6-11(14)9-4-2-1-3-8(9)10/h1-6H,7H2

Upstream product

• 316-68-7 4-fluoro-1-acetonaphthone 

Downstream Products

• 72326-42-2 1-(4-Fluoro-naphthalen-1-yl)-2-phenylamino-ethanone 
• 388-62-5 3-bromo-1-[2-(4-fluoro-[1]naphthyl)-2-oxo-ethyl]-pyridinium; bromide 

Relevant articles and documents

Novel Aryl-Substituted Pyrimidones as Inhibitors of 3-Mercaptopyruvate Sulfurtransferase with Antiproliferative Efficacy in Colon Cancer

The enzyme 3-mercaptopyruvate sulfurtransferase (3-MST) is one of the more recently identified mammalian sources of H2S. A recent study identified several novel 3-MST inhibitors with micromolar potency. Among those, (2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(naphthalen-1-yl)ethan-1-one) or HMPSNE was found to be the most potent and selective. We now took the central core of this compound and modified the pyrimidone and the arylketone sides independently. A 63-compound library was synthesized; compounds were tested for H2S generation from recombinant 3-MST in vitro. Active compounds were subsequently tested to elucidate their potency and selectivity. Computer modeling studies have delineated some of the key structural features necessary for binding to the 3-MST's active site. Six novel 3-MST inhibitors were tested in cell-based assays: they exerted inhibitory effects in murine MC38 and CT26 colon cancer cell proliferation; the antiproliferative effect of the compound with the highest potency and best cell-based activity (1b) was also confirmed on the growth of MC38 tumors in mice.

MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF

Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including inflammatory and immune diseases, having the structure of formula (I): an en

HETEROCYCLIC MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-κB ACTIVITY AND USE THEREOF

Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of Formula (I) or stereoisomers or prodrugs or solvates or pharmaceutically acceptable salts thereof, wherein A, B, J, K, Z, R, Ra, Rb, Rc, and Rd, are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.