388118-60-3Relevant articles and documents
Amino-substituted heterocycles as isosteres of trans-cinnamides: Design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding
Wang, Gary T.,Wang, Sheldon,Gentles, Robert,Sowin, Thomas,Leitza, Sandra,Reilly, Edward B.,Von Geldern, Thomas W.
, p. 195 - 201 (2007/10/03)
2-Amino-4-phenyl pyridine and, to a lesser extent, 4-amino-6-phenyl pyrimidine, were established as isosteres of trans-cinnamide moiety. Applying this isosterism to previously reported p-arylthio cinnamides resulted in the identification of 4-amino-6-(p-arylthio)phenyl-pyrimidines and 2-amino-4-(p-arylthio)phenyl-pyridines as potent antagonists of LFA-1/ICAM-1 binding.