3883-34-9

Basic information

• Product Name: C₂₂H₂₃NO
• Synonyms: C₂₂H₂₃NO
• CAS NO: 3883-34-9
• Molecular Weight: 317.431
• Mol File: 3883-34-9.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₃NO(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₃NO(3883-34-9)
• EPA Substance Registry System: C₂₂H₂₃NO(3883-34-9)

Safety Data

• Hazardous Substances Data: 3883-34-9(Hazardous Substances Data)

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 1174000-38-4 8-(4-methylbenzylidene)-2-amino-4-(4-methylphenyl)-5,6,7,8-tetrahydro-6-methyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile 
• 1195986-39-0 C₃₁H₂₈N₄ 
• 1426655-22-2 (E)-7-methyl-9-(4-methylbenzylidene)-2-(methylthio)-5-(p-tolyl)-6,7,8,9-tetrahydropyrimido[4,5-b][1,6]naphthyridin-4(3H)-one 
• 1426655-08-4 (E)-7-methyl-9-(4-methylbenzylidene)-2-(methylthio)-5-(p-tolyl)-6,7,8,9-tetrahydropyrimido[4,5-b][1,6]naphthyridin-4(3H,5H,10H)-one 
• 102756-58-1 1-methyl-3,5-bis-(4-methyl-benzyl)-1H-pyridin-4-one 
• 1623098-44-1 (E)-8-(4-methylbenzylidene)-4-(4-methylphenyl)-5,6,7,8-tetrahydro-6-methyl-2-phenylpyrido[4,3-d]pyrimidine 
• 1623098-51-0 (8E)-8-(4-methylbenzylidene)-4-(4-methylphenyl)-2,3,5,6,7,8-hexahydro-6-methyl-2-phenylpyrido[4,3-d]pyrimidine 

Relevant articles and documents

Synthesis and molecular modeling studies of indole-based antitumor agents

Indole-based compounds 30-63 were synthesized by the multi-component 1,3-dipolar cycloaddition reaction of 1-alkyl-3,5-bis(arylidene)-4-piperidones 11-25 with azomethine ylides (generated by the condensation of isatins 26-28 with sarcosine 29). The single crystal X-ray studies of 46 and 48 supported the regio- and stereoselectivity of the reaction. Most of the synthesized spiro-indoles exhibited potent antitumor properties against the HeLa (cervical cancer) cell line through in vitro sulfo-rhodamine-B bioassay, higher than that of cisplatin. Only compound 54 showed bio-potency against the HepG2 (hepatocellular cancer) cell line, comparable to that of doxorubicin hydrochloride (standard reference). 3D-Pharmacophore and 2D-QSAR studies were used to validate the observed biological data and determine the most important parameters controlling activity. The estimated bio-properties from the computational studies showed high approximations to the experimental data.

Amino functionalized mesoporous silica decorated with iron oxide nanoparticles as a magnetically recoverable nanoreactor for the synthesis of a new series of 2,4-diphenylpyrido[4,3-d]pyrimidines

(Fe2O3)-MCM-41-nPrNH2 as a magnetically recoverable nanoreactor, was prepared through the reaction of (Fe 2O3)-MCM-41 with 3-aminopropyltriethoxysilane in refluxing dry toluene. The catalyst with 10 wt% of loaded iron oxide nanoparticles was found to be a highly efficient nanocatalyst for the synthesis of a new class of 2,4-diphenylpyrido[4,3-d]pyrimidines under solvent free conditions in high to quantitative yields. By using an external magnet the catalyst was recovered and reused several times without any loss of efficiency. The prepared catalyst was characterized by transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray powder diffraction (XRD), and nitrogen physisorption measurements.

Microwave-assisted synthesis of pyrimido[4,5-b][1,6]naphthyridin-4(3H)-ones with potential antitumor activity

The 6,7,8,9-tetrahydropyrimido[4,5-b][1,6]naphthyridin-4(3H,5H,10H)-ones 4,5a-g and their oxidized forms 6,7a-g were obtained from the catalyst-free reaction of 6-amino-2-methylthiopyrimidin-4(3H)-one 3 and (E)-3,5- bis(benzylidene)-1-alkyl-4-piperidones