38923-36-3

Basic information

• Product Name: 2-(3,4-Dichlorophenyl)-2-oxoacetaldehyde
• Synonyms: 2-(3,4-Dichlorophenyl)-2-oxoacetaldehyde
• CAS NO: 38923-36-3
• Molecular Formula: C₈H₄Cl₂O₂
• Molecular Weight: 203.02216
• Mol File: 38923-36-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 303.3°Cat760mmHg
• Flash Point: 127.2°C
• Appearance: /
• Density: 1.427g/cm³
• Vapor Pressure: 0.000938mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 2-(3,4-Dichlorophenyl)-2-oxoacetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-Dichlorophenyl)-2-oxoacetaldehyde(38923-36-3)
• EPA Substance Registry System: 2-(3,4-Dichlorophenyl)-2-oxoacetaldehyde(38923-36-3)

Safety Data

• Hazardous Substances Data: 38923-36-3(Hazardous Substances Data)

Usage

Physical appearance

Yellow, crystalline substance

Odor

Strong, pungent

Usage

Production of pharmaceuticals and agrochemicals; intermediate in organic synthesis; synthesis of heterocyclic compounds; building block in the production of other chemicals

Health and environmental concerns

Potentially hazardous to human health and the environment

Handling and storage

Should be handled and stored with care

InChI:InChI=1/C8H4Cl2O2/c9-6-2-1-5(3-7(6)10)8(12)4-11/h1-4H

Upstream product

• 2632-10-2 2-bromo-1-(3,4-dichlorophenyl)ethanone 
• 2642-63-9 3',4'-dichloroacetophenone 

Downstream Products

• 59-61-0 dichloroisoproterenol 
• 185110-06-9 2-(3,4-dichlorophenyl)piperazine 
• 1616777-89-9 1-(3,4-dichlorophenyl)-2-hydroxy-3-(2-phenyloxazol-5-yl)propan-1-one 
• 1422715-24-9 2-(3,4-dichlorophenyl)-N-(pyridin-2-yl)imidazo[1,2-a]pyridin-3-amine 
• 1227411-47-3 3-(2-(3,4-dichlorophenyl)-1-hydroxy-2-oxoethyl)-3-methylindolin-2-one 
• 76849-82-6 5-(3,4-dichlorophenyl)-2(1H)-pyrazinone 4-oxide 
• 76849-89-3 5-(3,4-dichlorophenyl)-1-hydroxy-2(1H)-pyrazinone 
• 76849-84-8 2-chloro-5-(3,4-dichlorophenyl)pyrazine 

Relevant articles and documents

Visible-Light-Induced Regioselective Dicarbonylation of Indolizines with Oxoaldehydes via Direct C-H Functionalization

A metal-free system for regioselective dehydrogenative cross-couplings between indolizines and oxoaldehydes catalyzed by visible light under mild conditions has been described. As an atom economical and eco-friendly protocol, the reaction proceeds in good yields using inexpensive, readily available visible-light sources and the environmentally friendly oxidant oxygen. Various valuable 1,2-dicarbonyl derivatives attached to an indolizine core were easily accessed by the direct dicarbonylation of the sp2 C-H bond.

Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GSK-3β inhibitors. SAR studies focused on the phenyl moiety revealed that a 4-fluoro-2-methoxy group afforded potent inhibitory activity toward GSK-3β. Based on docking studies, new hydrogen bonding between the nitrogen atom of the piperazine moiety and the oxygen atom of the main chain of Gln185 has been indicated, which may contribute to increased activity compared with that of the corresponding phenylmorpholine analogues. Effect of the stereochemistry of the phenylpiperazine moiety is also discussed.

I2-promoted direct one-pot synthesis of 2-aryl-3-(pyridine-2- ylamino)imidazo[1,2-a]pyridines from aromatic ketones and 2-aminopyridines

An I2-promoted one-pot protocol was proposed for the synthesis of 2-aryl-3-(pyridine-2-ylamino)imidazo[1,2-a]pyridines from aromatic ketones and 2-aminopyridines. The present reaction proceeded well in the presence of I2 in DMSO, and it avoided the requirement of any metal, base, and ligand.