38923-57-8Relevant articles and documents
Process for the alkylation of active methylene compounds
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Paragraph 0157-0162, (2017/02/24)
The invention discloses an alkylation method of an active methylene compound. The method comprises the following steps: A, adding the active methylene compound to an inorganic alkali-first polar organic solvent mixing system to form a to-be-reacted mixture; B, adding an alkylating agent to the to-be-reacted mixture, filtering after reacting to obtain filtrate, and removing a solvent in the filtrate to obtain the alkylated active methylene compound. According to the method, the inorganic alkali is adopted as a proton abstraction reagent of the active methylene compound, so that the removal effect on alpha-hydrogen in the active methylene compound can be ensured, the alkylation reaction of the active methylene compound can be carried out under a mild condition, and the reaction safety is improved. Meanwhile, the inorganic alkali is low in price, so that the production cost of the alkylation reaction is reduced.
PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES
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Page/Page column 177-178, (2012/10/07)
Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
Novel isoxazolinyl spiropyrrolidinediones: 1,3-dipolar cycloaddition of 1-benzyl-3,3-dimethyl-5-methylenepyrrolidin-2,4-dione
Bathich, Yaser,Syed Monudeen Khan, Sharifah Edayu Binti,Hamzah, Ahmad Sazali
supporting information; experimental part, p. 1154 - 1156 (2011/07/09)
A simple and highly efficient methodology for the first synthesis of isoxazolinyl spiropyrrolidinedione starting from keto ester, is presented. Georg Thieme Verlag Stuttgart - New York.