38931-25-8

Basic information

• Product Name: 2,5-Cyclohexadiene-1,4-dione, 2,5-bis(1-aziridinyl)-3-methyl-6-(1-methylethyl)-
• CAS NO: 38931-25-8
• Molecular Formula: C14H18N2O2
• Molecular Weight: 246.309
• Mol File: 38931-25-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,5-Cyclohexadiene-1,4-dione, 2,5-bis(1-aziridinyl)-3-methyl-6-(1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Cyclohexadiene-1,4-dione, 2,5-bis(1-aziridinyl)-3-methyl-6-(1-methylethyl)-(38931-25-8)
• EPA Substance Registry System: 2,5-Cyclohexadiene-1,4-dione, 2,5-bis(1-aziridinyl)-3-methyl-6-(1-methylethyl)-(38931-25-8)

Safety Data

• Hazardous Substances Data: 38931-25-8(Hazardous Substances Data)

Upstream product

• 151-56-4 ethyleneimine 
• 490-91-5 thymoquinone 

Relevant articles and documents

Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents

The cytotoxicities and DNA cross-linking abilities of several alkyl- substituted diaziridinylquinones have been investigated. The cytotoxicities were determined in DT-diaphorase-rich (H460 and HT29) and -deficient (H596 and BE) cell lines. It was shown that the cytotoxicities in these cell lines correlated with the relative rates of reduction by the purified human enzyme and with the cross-linking efficiencies. The rates of reduction by DT- diaphorase were more dependent on the structures of the compounds than the reduction potentials, as determined by cyclic voltammetry. A computer model was also used to explain high efficiency of cross-linking and the GNC sequence selectivity of the reduced methyl-substituted diaziridinylquinones.