38952-61-3 Usage
Description
N,N-DiMethylMorpholine-4-carboxaMide, also known as N,N-Dimethylmorpholine-4-carboxamide, is an organic compound with potential applications in the pharmaceutical industry. It is characterized by its unique chemical structure, which allows it to interact with specific biological targets.
Uses
Used in Pharmaceutical Industry:
N,N-DiMethylMorpholine-4-carboxaMide is used as a PDE4 inhibitor for the treatment of PDE4 related diseases. PDE4 inhibitors are a class of drugs that target phosphodiesterase 4, an enzyme involved in various cellular processes, including inflammation and immune response. By inhibiting PDE4, N,N-DiMethylMorpholine-4-carboxamide can help regulate these processes and provide therapeutic benefits for patients suffering from PDE4 related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 38952-61-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,9,5 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 38952-61:
(7*3)+(6*8)+(5*9)+(4*5)+(3*2)+(2*6)+(1*1)=153
153 % 10 = 3
So 38952-61-3 is a valid CAS Registry Number.
38952-61-3Relevant articles and documents
Re-evaluating the stability of COMU in different solvents
Kumar, Ashish,Jad, Yahya E.,de la Torre, Beatriz G.,El-Faham, Ayman,Albericio, Fernando
, p. 763 - 768 (2017/09/12)
COMU is uronium-type coupling reagent based on OxymaPure. It showed several advantages over classical benzotriazole-based coupling reagents such as higher solubility, water-soluble byproduct, and monitoring the reaction by changing of color. Although COMU is well known to perform excellent in solution, but its hydrolytic stability in DMF limits its use in automatic peptide synthesizer. Herein, we evaluated the hydrolytic stability of COMU in γ-valerolactone (GVL), acetonitrile (ACN) and N-formylmorpholine (NFM) and compared its stability against DMF. The stability of COMU after 24?h was found to be 88 and 89% in GVL and ACN, respectively, when compared in DMF (14%). Further, the demanding Aib-ACP decapeptide and JR decapeptide were successfully synthesized using COMU dissolved in GVL or ACN while Fmoc amino acids were dissolved in DMF. Copyright
