38969-08-3Relevant articles and documents
Novel plastoquinone analogs containing benzocaine and its analogs: structure‐based design, synthesis, and structural characterization
Bayrak, Nilüfer,Y?ld?z, Mahmut,Y?ld?r?m, Hatice,Matarac?-Kara, Emel,Tuyun, Ama? Fatih
, p. 2125 - 2141 (2021/02/11)
Introducing new biologically active organic molecules or their analogs into the pharmaceutically important molecules significantly enables the discovery and development of the medicines that improve the health of patients. Chemical synthesis has a key role in pharmaceutical research and development, aiming to design and build molecules with the essential biological activity needed in drugs. For that reason, herein, three series of novel PQ analogs (the nonhalogenated (PQ1-6) and the halogenated PQ analogs (BrPQ1-6 and ClPQ1-6)) containing benzocaine and its analogs were designed and synthesized starting from the commercially available dimethylhydroquinone (1) with benzocaine and its analogs. The structures of all synthesized analogs were characterized by using spectroscopic methods. The in vitro antibacterial and antifungal activities were evaluated for the PQ analogs.
ARYL- AND HETEROARYL-RESORUFIN DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISORDERS AND LIVER AND KIDNEY DISORDERS
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Paragraph 00209, (2018/07/31)
Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for tr
Oxidation Using Quaternary Ammonium Polyhalides. VIII. Oxidation of 1,4-Benzenediols with Benzyltrimethylammonium Tribromide
Kajigaeshi, Shoji,Morikawa, Yukihiro,Fujisaki, Shizuo,Kakinami, Takaaki,Nishihira, Keigo
, p. 336 - 338 (2007/10/02)
The reaction of 1,4-benzenediols with 1.1 equiv of benzyltrimethylammonium tribromide in dichloromethane in the presence of aqueous sodium acetate at room temperature gave 2,5-cyclohexadiene-1,4-diones in good yields.On the other hand, the reaction of 1,4-benzenediols with a large excess of the reagent in aqueous acetic acid at 40-60 deg C gave polybromo-substituted 2,5-cyclohexadiene-1,4-diones in good yields.