38980-93-7

Basic information

• Product Name: 4-(4-NITROPHENYL)-1H-IMIDAZOLE
• Synonyms: 4-(4-NITROPHENYL)-1H-IMIDAZOLE;4-(4'-Nitrophenyl)imidazole;5-(4-Nitro-phenyl)-1H-imidazole;4-(4-NITROPHENYL)-1H-IMIDAZOLE(WXG02129)
• CAS NO: 38980-93-7
• Molecular Formula: C₉H₇N₃O₂
• Molecular Weight: 189.17078
• Product Categories: Imidazol&Benzimidazole
• Mol File: 38980-93-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 471.2 °C at 760 mmHg
• Flash Point: 238.8 °C
• Appearance: /
• Density: 1.369g/cm³
• Vapor Pressure: 1.34E-08mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: 4-(4-NITROPHENYL)-1H-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-NITROPHENYL)-1H-IMIDAZOLE(38980-93-7)
• EPA Substance Registry System: 4-(4-NITROPHENYL)-1H-IMIDAZOLE(38980-93-7)

Safety Data

• Hazardous Substances Data: 38980-93-7(Hazardous Substances Data)

Usage

General Description

4-(4-Nitrophenyl)-1H-imidazole is a chemical compound with the molecular formula C9H7N3O2. It is a yellow crystalline solid with a molecular weight of 189.18 g/mol. 4-(4-NITROPHENYL)-1H-IMIDAZOLE is commonly used as a pharmaceutical intermediate in the synthesis of various imidazole derivatives. It is known for its antifungal, antibacterial, and anti-inflammatory properties, making it a valuable component in the development of new drugs and treatments. Additionally, 4-(4-Nitrophenyl)-1H-imidazole is also used in biochemical research as a reagent for the detection and quantification of certain enzymes and proteins. Overall, this compound plays an important role in the pharmaceutical and biomedical industries due to its versatile applications.

InChI:InChI=1/C9H7N3O2/c13-12(14)8-3-1-7(2-4-8)9-5-10-6-11-9/h1-6H,(H,10,11)

Upstream product

• 64-17-5 ethanol 
• 13707-46-5 N-tosyl-4-nitrobenzaldimine 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 89108-47-4 4-diazo-4H-imidazole 
• 98-95-3 nitrobenzene 
• 586-78-7 para-nitrophenyl bromide 
• 555-16-8 4-nitrobenzaldehdye 
• 99-81-0 4-Nitrophenacyl bromide 
• 670-95-1 4-Phenylimidazole 
• 70-11-1 α-bromoacetophenone 
• 670-96-2 2-Phenylimidazole 
• 5425-81-0 2-amino-1-(4-nitrophenyl)ethanone hydrochloride 
• 77287-34-4 formamide 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 1354280-05-9 2-cyano-3-cyclopropyl-1-[4-(1H-imidazol-4-yl)phenyl]guanidine 
• 1354280-07-1 2-cyano-1-[3-(1H-imidazol-4-yl)phenyl]-3-isobutylguanidine 
• 1354280-10-6 2-cyano-1-[3-(1H-imidazol-4-yl)phenyl]-3-(3-phenylpropyl)guanidine 
• 1354280-13-9 2-cyano-1-[3-(1H-imidazol-4-yl)phenyl]-3-[2-(phenylthio)ethyl]guanidine 
• 1301198-66-2 1,1-dimethylethyl 3-[4-(4-{[1-methyl-3-({[(1-methylethyl)oxy]carbonyl}amino)-3-oxopropyl]amino}phenyl)-1H-imidazol-1-yl]propanoate 
• 1301198-68-4 1,1-dimethylethyl 3-[4-(4-nitrophenyl)-1H-imidazol-1-yl]propanoate 
• 1301198-63-9 1,1-dimethylethyl [4-(4-nitrophenyl)-1H-imidazol-1-yl]acetate 
• 1301198-67-3 1,1-dimethylethyl 3-[4-(4-aminophenyl)-1H-imidazol-1-yl]propanoate 
• 1301198-62-8 1,1-dimethylethyl [4-(4-aminophenyl)-1H-imidazol-1-yl]acetate 
• 1301198-61-7 1,1-dimethylethyl [4-(4-{[1-methyl-3-({[(1-methylethyl)oxy]carbonyl}amino)-3-oxopropyl]amino}phenyl)-1H-imidazol-1-yl]acetate 
• 103298-41-5 1-methyl-4-(4-nitrophenyl)-1H-imidazole 
• 72798-67-5 5-(4-aminophenyl)-3H-imidazole-dihydrochloride 
• 154164-61-1 4-(1H-imidazol-4-yl)-2-nitroacetanilide 
• 72798-74-4 4-(3H-Imidazol-4-yl)-2-nitro-phenylamine 

Relevant articles and documents

Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities

This study evaluated the potential use of senescence-inducing small molecules in the treatment of melanoma. We screened commercially available small-molecule libraries with high-throughput screening and high-content screening image-based technology. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold-induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogues were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within.

Tetrahydroquinoline Derivatives And Their Pharmaceutical Use

Tetrahydroquinoline compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.

TETRAHYDROQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE

Tetrahydroquinoline compounds of Formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.