39011-90-0

Basic information

• Product Name: Albiflorin
• Synonyms: (1R,3R,4R,6S,9S)-9-[(Benzoyloxy)Methyl]-1-(beta-D-glucopyranosyloxy)-4-hydroxy-6-Methyl-7-oxatricyclo[4.3.0.03,9]nonan-8-one;Albiflorin, froM Paeonia lactiflora;Albiflorin 9-((Benzoyloxy)methyl)-1-(beta-D-glucopyranosyloxy)-4-hydroxy-6-methyl-7-oxatricyclononan-8-one;ALBIFLORIN;Albiflorin std;9-((Benzoyloxy)methyl)-1-(beta-D-glucopyranosyloxy)-4-hydroxy-6-methyl-7-oxatricyclononan-8-one;[(benzoyloxy)methyl]-1-(β-D-glucopyranosyloxy)-;4-hydroxy-6-methyl-, (1R, 3R, 4R, 6S)-
• CAS NO: 39011-90-0
• Molecular Formula: C₂₃H₂₈O₁₁
• Molecular Weight: 480.46
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Miscellaneous Natural Products;The group of Paeoniflorin
• Mol File: 39011-90-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 722.054 °C at 760 mmHg
• Flash Point: 248.934 °C
• Appearance: /
• Density: 1.587 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.662
• Storage Temp.: ?20°C
• PKA: 12.84±0.70(Predicted)
• CAS DataBase Reference: Albiflorin(CAS DataBase Reference)
• NIST Chemistry Reference: Albiflorin(39011-90-0)
• EPA Substance Registry System: Albiflorin(39011-90-0)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 39011-90-0(Hazardous Substances Data)

Usage

Biological Functions

Albiflorin is a natural product isolated from Paeoniae Radix. It enhances mitochondrial function to suppress antimycin A-induced oxidative damage via the preservation of cytochrome c and cardiolipin. Also it may reduce or prevent osteoblast degeneration in osteoporosis.

Biological Activity

Albiflorin is a natural phenolic compound that has been shown to be an inhibitor of toll-like receptor (TLR) 4.

in vitro

Albiflorin can modulate the TLR-induced inflammatory response by inhibiting the production of proinflammatory cytokines, such as IL-6, IL-8, and TNF-α. This compound also inhibits matrix metalloproteinase activity in tubulointerstitial injury, leading to decreased interstitial inflammation and proteinuria. Albiflorin has been shown to be effective at low doses in experimental models of rheumatoid arthritis. It is believed that this effect may be due to its ability to inhibit TLR4 expression or activation.

InChI:InChI=1/C23H28O11/c1-21-8-13(25)12-7-23(21,33-19-17(28)16(27)15(26)14(9-24)32-19)22(12,20(30)34-21)10-31-18(29)11-5-3-2-4-6-11/h2-6,12-17,19,24-28H,7-10H2,1H3/t12?,13-,14-,15-,16+,17-,19+,21+,22?,23+/m1/s1