39020-79-6

Basic information

• Product Name: N-ALLYLOXYPHTHALIMIDE
• Synonyms: N-ALLYLOXYPHTHALIMIDE;2-(ALLYLOXY)-1H-ISOINDOLE-1,3(2H)-DIONE;Allyloxyphtalimide;N-Allyloxyphtalimide;2-Allyloxy-1,3-isoindolinedione;2-(Allyloxy)isoindoline-1,3-dione;O-1-allylhydroxyphthalimide;N-Allyloxyphthalimide
• CAS NO: 39020-79-6
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.19
• Product Categories: N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Phthalimides
• Mol File: 39020-79-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 59.0 to 63.0 °C
• Boiling Point: 318.2 °C at 760 mmHg
• Flash Point: 146.2 °C
• Appearance: Off-white to white powder
• Density: 1.3 g/cm³
• Vapor Pressure: 0.000367mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-ALLYLOXYPHTHALIMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ALLYLOXYPHTHALIMIDE(39020-79-6)
• EPA Substance Registry System: N-ALLYLOXYPHTHALIMIDE(39020-79-6)

Safety Data

• Hazardous Substances Data: 39020-79-6(Hazardous Substances Data)

Usage

Description

N-Allyloxyphthalimide is an organic compound that exists as an off-white to white powder. It is a valuable intermediate for various organic synthesis processes due to its unique chemical properties and reactivity.

Uses

Used in Organic Synthesis:
N-Allyloxyphthalimide is used as a key intermediate in the synthesis of various organic compounds. Its chemical properties allow it to participate in a range of reactions, making it a versatile building block for creating diverse molecules with potential applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-Allyloxyphthalimide is used as a starting material for the development of new drugs. Its unique structure can be modified and functionalized to create novel drug candidates with potential therapeutic properties.
Used in Chemical Research:
N-Allyloxyphthalimide is also utilized in academic and industrial research settings to study various chemical reactions and mechanisms. Its reactivity and structural features make it an interesting subject for exploring new synthetic pathways and understanding the underlying chemistry.
Used in Material Science:
In the field of material science, N-Allyloxyphthalimide can be used to develop new materials with specific properties. Its chemical structure can be tailored to create compounds with desired characteristics, such as improved stability, reactivity, or selectivity, which can be applied in various technological applications.

InChI:InChI=1/C11H9NO3/c1-2-7-15-12-10(13)8-5-3-4-6-9(8)11(12)14/h2-6H,1,7H2

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 556-56-9 allyl iodid 
• 107-05-1 3-chloroprop-1-ene 
• 107-18-6 allyl alcohol 
• 106-95-6 allyl bromide 

Downstream Products

• 6542-54-7 O-Allylhydroxylamine 
• 38945-21-0 O-allylhydroxylamine hydrochloride 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 19357-07-4 2-(benzylcarbamoyl)benzoic acid 
• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 
• 38228-99-8 N,N'-dibenzylphthalamide 
• 2142-01-0 N-benzylphthalimide 

Relevant articles and documents

Synthetic Study on Acremoxanthone A: Construction of Bicyclo [32.2]nonane CD Skeleton and Fusion of AB Rings

Toward the total synthesis of acremoxanthone A, a model study has revealed a convergent approach to construct the ABCDE ring system. The key steps include: (1) an effective construction of the bicyclo[3.2.2]nonane skeleton, (2) protocol for generating the bridgehead anion and trapping, and (3) 1,3-dipolar cycloaddition of a nitrile oxide to the internal alkene.

A phthalimidation protocol that follows protein defined parameters

This work outlines the first phthalimidation protocol suitable for protein labeling and performed in aqueous media at room temperature and neutral pH with no catalyst or co-reagent required. The methodology is suitable for a range of amines and its efficiency was determined with chemoselective and site-selective protein labeling. This journal is

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

A novel series of benzhydroxamate esters derived from their precursor anthranilic acids have been prepared and have been identified as potent MEK inhibitors. 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzam ide, CI-1040, was the first MEK inhibitor to demonstrate in vivo activity in preclinical animal models and subsequently became the first MEK inhibitor to enter clinical trial. CI-1040 suffered however from poor exposure due to its poor solubility and rapid clearance, and as a result, development of the compound was terminated. Optimization of the diphenylamine core and modification of the hydroxamate side chain for cell potency, solubility, and exposure with oral delivery resulted in the discovery of the clinical candidate N-(2,3-dihydroxy-propoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-b enzamide PD 0325901.