39191-07-6

Basic information

• Product Name: 3-CHLORO-N-METHYLBENZYLAMINE
• Synonyms: 3-CHLORO-N-METHYLBENZYLAMINE;M-CHLORO-N-METHYLBENZYLAMINE;N-(3-CHLOROBENZYL)-N-METHYLAMINE;3-Chloro-N-methylbenzenemethanamine;N-Methyl-3-chlorobenzylamine;3-Chloro-N-methylbenzylamine ,97%;3-CHLORO-N-METHYLBEN;N-(3-Chlorobenzyl)-N-methylamine, Tech.
• CAS NO: 39191-07-6
• Molecular Formula: C₈H₁₀ClN
• Molecular Weight: 155.62
• EINECS: 254-343-8
• Product Categories: Polyamines;Amines;C8;Nitrogen Compounds
• Mol File: 39191-07-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 97 °C0.6 mm Hg(lit.)
• Flash Point: 115 °F
• Appearance: colorless liquid.
• Density: 1.072 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.232mmHg at 25°C
• Refractive Index: n20/D 1.5395(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.34±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3-CHLORO-N-METHYLBENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-N-METHYLBENZYLAMINE(39191-07-6)
• EPA Substance Registry System: 3-CHLORO-N-METHYLBENZYLAMINE(39191-07-6)

Safety Data

• Hazard Codes: Xn
• Statements: 10-22-38-41
• Safety Statements: 16-26-36/37/39
• RIDADR: UN 1993 3/PG 1
• WGK Germany: 2
• TSCA: Yes
• HazardClass: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 39191-07-6(Hazardous Substances Data)

Usage

General Description

3-Chloro-N-methylbenzylamine is an organic compound with the chemical formula C8H10ClN. It is a clear to pale yellow liquid with a pungent odor. This chemical is commonly used as an intermediate for the synthesis of pharmaceuticals and agrochemicals. It is also used as a reagent in organic synthesis for the preparation of various compounds. 3-Chloro-N-methylbenzylamine is considered to be a hazardous substance, as it can cause irritation to the skin, eyes, and respiratory system upon contact or inhalation. Proper safety precautions should be taken when handling this chemical, and it should be stored and disposed of according to relevant regulations.

InChI:InChI=1/C8H10ClN/c1-10-6-7-3-2-4-8(9)5-7/h2-5,10H,6H2,1H3/p+1

Upstream product

• 67-56-1 methanol 
• 126799-85-7 3-chlorobenzylazide 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 74-89-5 methylamine 
• 593-51-1 methylamine hydrochloride 
• 587-04-2 m-Chlorobenzaldehyde 
• 620-20-2 1-Chloro-3-chloromethyl-benzene 
• 90434-25-6 1-(3-chlorophenyl)-N-methylmethanimine 
• 766-80-3 1-bromomethyl-3-chlorobenzene 

Downstream Products

• 876476-09-4 (3-bromo-benzyl)-(3-chloro-benzyl)-methyl-amine 
• 112534-56-2 N-(3-chloro-benzyl)-N-methyl-glycine nitrile 
• 1174903-43-5 3-[[(3-chlorobenzyl)-methyl-amino]methyl]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2(3H)-one 
• 1386979-64-1 2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {2-chloro-5-[(3-chloro-benzyl)-methyl-carbamoyl]-phenyl}-amide 
• 1386979-62-9 2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[(3-chloro-benzyl)-methyl-carbamoyl]-2-methyl-phenyl}-amide 
• 90434-25-6 1-(3-chlorophenyl)-N-methylmethanimine 

Relevant articles and documents

Selective synthesis of mono- and di-methylated amines using methanol and sodium azide as C1 and N1 sources

A Ru(ii) complex mediated synthesis of various N,N-dimethyl and N-monomethyl amines from organic azides using methanol as a methylating agent is reported. This methodology was successfully applied for a one-pot reaction of bromide derivatives and sodium azide in methanol. Notably, by controlling the reaction time several N-monomethylated and N,N-dimethylated amines were synthesized selectively. The practical applicability of this tandem process was revealed by preparative scale reactions with different organic azides and synthesis of an anti-vertigo drug betahistine. Several kinetic experiments and DFT studies were carried out to understand the mechanism of this transformation.

BENZAMIDE COMPOUNDS AS ROR GAMMA MODULATORS

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, R1, R2, R3, R4, R5, n and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AS KINASE INHIBITORS

The present invention is intended to provide a compound or a pharmacologically acceptable salt thereof which is useful in the treatment of a tumor through its ROS1 kinase enzyme activity inhibitory effect and NTRK kinase enzyme inhibitory effect. The present invention provides a compound having an imidazo[1,2-b]pyridazine structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, and a pharmaceutical composition comprising the compound. In the formula, R1, G, T, Y1, Y2, Y3, and Y4 are as defined herein.