392-04-1 Usage
Description
METHYL 4-FLUORO-2-HYDROXYBENZOATE is an organic compound that serves as a valuable synthetic intermediate in the chemical industry. It is characterized by its unique molecular structure, which features a fluorine atom at the 4-position and a hydroxyl group at the 2-position on a benzoate backbone. METHYL 4-FLUORO-2-HYDROXYBENZOATE is known for its potential applications in the development of various pharmaceutical compounds and other chemical products.
Uses
Used in Pharmaceutical Industry:
METHYL 4-FLUORO-2-HYDROXYBENZOATE is used as a synthetic intermediate for the preparation of benzo[d]isoxazol-3-ol, which are known as D-amino acid oxidase inhibitors. These inhibitors play a crucial role in the development of drugs targeting various diseases and conditions, as they help regulate the activity of D-amino acid oxidase, an enzyme involved in the metabolism of D-amino acids.
Additionally, METHYL 4-FLUORO-2-HYDROXYBENZOATE is utilized in the discovery and synthesis of hydroxy-indazole-carboxamides. These compounds have been identified as potential inhibitors of Hsp90, a heat shock protein that plays a significant role in cellular protein folding and stabilization. Inhibiting Hsp90 can have therapeutic implications in the treatment of various diseases, including cancer, as it can disrupt the stability of oncogenic proteins and hinder their function.
Check Digit Verification of cas no
The CAS Registry Mumber 392-04-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 392-04:
(5*3)+(4*9)+(3*2)+(2*0)+(1*4)=61
61 % 10 = 1
So 392-04-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H7FO3/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4,10H,1H3
392-04-1Relevant articles and documents
Discovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold
Chen, Weixiong,Feng, Bo,Han, Sheng,Wang, Peipei,Chen, Wuhong,Zang, Yi,Li, Jia,Hu, Youhong
supporting information, (2022/01/14)
The COVID-19 pandemic has drastically impacted global economies and public health. Although vaccine development has been successful, it was not sufficient against more infectious mutant strains including the Delta variant indicating a need for alternative treatment strategies such as small molecular compound development. In this work, a series of SARS-CoV-2 main protease (Mpro) inhibitors were designed and tested based on the active compound from high-throughput diverse compound library screens. The most efficacious compound (16b-3) displayed potent SARS-CoV-2 Mpro inhibition with an IC50 value of 116 nM and selectivity against SARS-CoV-2 Mpro when compared to PLpro and RdRp. This new class of compounds could be used as potential leads for further optimization in anti COVID-19 drug discovery.
BENZOTHIOPHENE, THIENOPYRIDINE AND THIENOPYRIMIDINE DERIVATIVES FOR THE MODULATION OF STING
-
Page/Page column 96-97, (2021/02/12)
A compound of formula (I); wherein: W is O or NH; A1 1 is CRAA or N; A22 is CRBB or N; A3A3 is CRCC or N; A44 is CRDD or N; where no more than two of A11, A
ASK1 INHIBITING AGENTS
-
Page/Page column 176, (2018/09/08)
Provided are compounds of Formulas (I'), (I), (II') and (II), or pharmaceutically acceptable salts thereof, and methods for their use and production.
