392-13-2 Usage
Description
5-Fluoro-3-methylindole is an organic compound characterized by its off-white powder form. It is a derivative of the indole family, with a fluorine atom at the 5th position and a methyl group at the 3rd position. 5-Fluoro-3-methylindole is of interest due to its unique chemical properties and potential applications in various fields.
Uses
Used in Research Applications:
5-Fluoro-3-methylindole is used as a research compound for studying its ionization potential and the origin of nonexponential tryptophan fluorescence decay in proteins. This application is significant for understanding the behavior of proteins and their interactions at the molecular level, which can have implications in various biological and pharmaceutical processes.
Used in Chemical Synthesis:
As a member of the indole family, 5-Fluoro-3-methylindole can be utilized as a building block or intermediate in the synthesis of more complex organic molecules. Its unique substitution pattern may offer specific reactivity or selectivity in chemical reactions, making it a valuable component in the development of new pharmaceuticals, agrochemicals, or other specialty chemicals.
Used in Analytical Chemistry:
5-Fluoro-3-methylindole's fluorescence properties can be exploited in analytical chemistry for the detection and quantification of various substances. By studying the nonexponential fluorescence decay of tryptophan, researchers can gain insights into the structural and environmental factors that influence fluorescence, which can be applied to develop more sensitive and selective analytical methods.
Used in Pharmaceutical Development:
Given its potential applications in research and chemical synthesis, 5-Fluoro-3-methylindole may also find use in the development of new pharmaceuticals. Its unique structure could be leveraged to design drugs with novel mechanisms of action or improved pharmacokinetic properties, contributing to the advancement of therapeutic options for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 392-13-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 2 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 392-13:
(5*3)+(4*9)+(3*2)+(2*1)+(1*3)=62
62 % 10 = 2
So 392-13-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H8FN/c1-6-5-11-9-3-2-7(10)4-8(6)9/h2-5,11H,1H3
392-13-2Relevant articles and documents
Annulative π-Extension (APEX) of Indoles to Pyrido[1,2- a]indoles Using 4-Oxo Peroxides as C4 Units
Wang, Xin,Lou, Chenhao,Lv, Leiyang,Li, Zhiping
, p. 5978 - 5982 (2021/08/03)
Annulative π-extension (APEX) of 3-substituted indoles to pyrido[1,2-a]indoles is developed by using 4-oxo peroxides as π-extending reagents, which are employed as versatile C4 building blocks. This transformation is initiated by Br?nsted acid-mediated Hock rearrangement of the peroxyl group. Notably, the pyrido[1,2-a]indole products are obtained by elimination of the indole moiety from the corresponding dihydropyrido[1,2-a]indoles, which could be selectively formed at room temperature.
Synthesis of Pyrido[2,3-b]indole Derivatives via Rhodium-Catalyzed Cyclization of Indoles and 1-Sulfonyl-1,2,3-triazoles
An, Yuehui,Chen, Yidian,Duan, Shengguo,Li, Chuan-Ying,Xu, Ze-Feng,Xue, Bing,Zhang, Wan
, (2020/04/22)
Acyloxy-substituted α,β-unsaturated imines generated in situ from triazoles can act as aza-[4 C] synthons and be trapped by indoles in a stepwise [4 + 2] cycloaddition reaction, thus providing rapid access to valuable pyrido[2,3-b]indoles in high yields. Attractive features of this reaction system include operational simplicity, readily available substrates, construction of sterically demanding quaternary centers, and convenient derivatization using triflate. (Figure presented.).
N-Alkylation-Initiated Redox-Neutral [5 + 2] Annulation of 3-Alkylindoles with o-Aminobenzaldehydes: Access to Indole-1,2-Fused 1,4-Benzodiazepines
Wang, Shuai,Shen, Yao-Bin,Li, Long-Fei,Qiu, Bin,Yu, Liping,Liu, Qing,Xiao, Jian
, p. 8904 - 8908 (2019/11/19)
Described herein is an unprecedented N-Alkylation-initiated redox-neutral [5 + 2] annulation of 3-Alkylindoles with o-Aminobenzaldehydes via a cascade N-Alkylation/dehydration/[1,5]-hydride transfer/Friedel-Crafts alkylation sequence. A series of indole-1,2-fused 1,4-benzodiazepines are facilely constructed in moderate to good yields in one step. This protocol features excellent regioselectivity, metal-free conditions, high step economy, and wide substrate scope.
